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Cytogenetic studies onH-2 alloantigenic loss variants selected from heterozygous tumors

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Abstract

Transplantation, serological, and cytogenetic analyses on alloantigenic loss variants selected from heterozygous mouse tumors induced in F1 animals demonstrate that both 17 chromosomes have been maintained in all variants despite complete loss of oneH-2 complex. Small, subchromosomal deletion or mutation remains the most plausible explanation for alloantigenic loss variant formation in diploid or near-diploid heterozygous tumors.

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Authors and Affiliations

  1. Department of Tumor Biology, Karolinska Institutet, S-10401, Stockholm 60, Sweden

    Francis Wiener, Tina Dalianis & George Klein

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  1. Francis Wiener
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  2. Tina Dalianis
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  3. George Klein
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Wiener, F., Dalianis, T. & Klein, G. Cytogenetic studies onH-2 alloantigenic loss variants selected from heterozygous tumors. Immunogenetics 2, 63–72 (1975). https://doi.org/10.1007/BF01572275

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  • DOI: https://doi.org/10.1007/BF01572275

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