Medical Oncology

, Volume 12, Issue 3, pp 167–176 | Cite as

Molecular pathology of low grade malignant lymphomas

  • Howard Ratech


During the last ten years the combined efforts of pathologists and molecular biologists have helped define several new lymphoma diagnostic categories. In particular, the recognition of chromosomal translocations which have activated the BCL1 and BCL2 proto-oncogenes have strong associations with specific types of non-Hodgkin’s malignant lymphomas such as mantle cell lymphoma and follicular center cell lymphoma, respectively. This review will attempt to summarize our current understanding regarding the contributions of BCL1 and BCL2 to lymphomagenesis and diagnosis.


lymphoma BCL1 BCL2 mantle cell lymphoma follicular lymphoma molecular diagnosis DNA 


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Copyright information

© Humana Press Inc. 1995

Authors and Affiliations

  • Howard Ratech
    • 1
  1. 1.Department of PathologyAlbert Einstein College of Medicine/Montefiore Medical CenterBronxUSA

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