Molecular biology of leukemia for the clinician
- 33 Downloads
Although significant progress has been made in the treatment of the acute leukemias, therapies are generally non-specific and not targeted at the biologic defects underlying these diseases. Consequently, treatment results are suboptimal. The development of leukemic cell phenotype-specific therapies is hampered by our limited knowledge of the biology of acute leukemias. That characterizing the genetic defect may revolutionize treatment approach and disease outcome has recently been proven in acute promyelocytic leukemia. Once identified, genes involved in the pathogenesis of leukemic subtypes not only allow for improved diagnosis and monitoring of minimal residual leukemic cells but may ultimately lead to the development of innovative drug strategies that aim at the inhibition of disease-related genes or their encoded proteins. The focus of this review is to familiarize the practicing physician with some principles of molecular biology and with its current and future goals with respect to leukemia.
KeywordsLeukemia molecular biology
Unable to display preview. Download preview PDF.
- 7.Paietta, E. (1995) Immunobiology of acute leukemia. In: P.H. Wiernik, G.P. Canellos, R.A. Kyle and J.P. Dutcher (eds)Neoplastic Diseases of the Blood, 3rd Edn, New York: Churchill Livingston (in press).Google Scholar
- 10.Paietta, E., Andersen, J., Rowe, J., Cassileth, P. and Wiernik, P.H. (1995) Myeloid blast cell maturation determines response in adult de novo acute myeloid leukemia (AML): A response-driven antigen expression analysis in 382 Eastern Cooperative Oncology Group (ECOG) patients.Proc. Am. Soc. Clin. Oncol. (in press).Google Scholar
- 11.Paietta, E., Andersen, J., Racevskis, J., Ashigbi, M., Cassileth, P. and Wiernik, P.H. (1995) Modulation of multidrug resistance inde novo adult acute myeloid leukemia: Variable efficacy of reverting agentsin vitro. Blood Rev. (in press).Google Scholar
- 26.Frankel, S.R. (1993) Acute promyelocytic leukemia. New insights into diagnosis and therapy.Hematol/Oncol. Clinics North Am. 7, 109.Google Scholar
- 29.Geurts van Kessel, A., de Leeuw, H., Dekker, E.J., Rijks, L., Spurr, N., Ledbetter, D., Kootwijk, E. and Vaessen, M.J. (1991) Localization of the cellular retinoic acid binding protein (CRABP) gene relative to the acute promyelocytic leukemia-associated breakpoint on human chromosome 15.Hum. Genet. 87, 201.PubMedCrossRefGoogle Scholar
- 30.Tallman, M., Gallagher, R.E. and Wiernik, P.H. (1995) Acute promyelocytic leukemia. In: P.H. Wiernik, G.P. Canellos, R.A. Kyle and J.P. Dutcher (eds)Neoplastic Diseases of the Blood, 3rd edn. New York: Churchill Livingston (in press).Google Scholar
- 35.Cone, R.W. and Fairfax, M.R. (1993) Protocol for ultraviolet irradiation of surfaces to reduce PCR contamination.PCR Methods and Applications.3, S15. Cold Spring Harbor Laboratory ISSN.Google Scholar
- 36.Lestingi, T.M. and Hooberman, A.L. (1993) Philadelphia chromosome-positive acute lymphoblastic leukemia.Hematol/Oncol Clinics North Am. 7, 161.Google Scholar