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Identity of murine lymphocyte alloantigens DAG, ALA-1, Ly-8, and Ly-6?

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Abstract

The DAG, Ala-1, Ly-8 and Ly-6 lymphocyte membrane alloantigens, identified by immune sera raised in different strain combinations, were originally thought to be distinct specificities. With the use of a congenic strain, BALB-DAG, we have now further evidence for antigenic identity based on serological and genetic criteria.

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Abbreviations

Ala:

activated lymphocyte antigen

Ly:

lymphocyte antigen

DAG+ :

indicates presence of DAG alloantigen, and DAG−=its absence, on the lymphocyte surface

RI:

recombinant inbred

SDP:

strain distribution pattern

LNC:

lymph node cells

PBL:

peripheral blood lymphocyte

B10, B6:

C57BL/10 and BL/6, respectively

References

  • Bailey, D. W.: Recombinant-inbred strains.Transplantation 11:325–327, 1971

    PubMed  Google Scholar 

  • Brand, D. L., Ray, J. R., Hare, D. B., Kayhoe, D. E., and McClelland, J. D.: Preliminary trials towards standardisation of leucocyte typing.In P. I. Terasaki (ed.):Histocompatibility Testing 1970, p. 357, Munksgaard, Copenhagen, 1970

    Google Scholar 

  • Feeney, A. J. and Hämmerling, U.: Differentiation of murine T and B lymphocytes from resting to effector cells as characterised by Ala-1.In N. Müller-Berat (ed.):Progress in Differentiation Research, pp. 551–558, North-Holland Publishing Co., Amsterdam, 1976 a

    Google Scholar 

  • Feeney, A. J. and Hämmerling, U.: Ala-1: a murine alloantigen of activated lymphocytes. I. Serological analysis of mitogen-stimulatedT andB cells.Immunogenelics 3:369–379, 1976b

    Google Scholar 

  • Feeney, A. J.: Expression of Ala-I on T and B effector cells.In E. Sercarz, L. A. Herzenberg, and C. F. Fox (eds.):Immune System: Genetics and Regulation, ICN-UCLA Symposium on Molecular and Cellular Biology, PP. 227–283, Academic Press, New York, 1977

    Google Scholar 

  • Feeney, A. J. and Hämmerling, U.: Ala-1: a murine alloantigen of activated lymphocytes II. T and B effector cells express Ala-1.J. Immunol. 118:1488–1494, 1977

    PubMed  Google Scholar 

  • Feeney, A. J.: Expression of Ly-6 on activated T and B cells: possible identity with Ala-1.Immunogenetics 7:537–543, 1978

    Google Scholar 

  • Festenstein, H.: Immunogenetic and biological aspects ofin vitro lymphocyte allo-transformation (M.L.R.) in the mouse.Transplant Rev. 15:62–88, 1973

    PubMed  Google Scholar 

  • Festenstein, H.: Pertinent features of M locus determinants including revised nomenclature and strain distribution.Transplantation 18:555–557, 1974

    PubMed  Google Scholar 

  • Flaherty, L. and Bennett, D.: Histoincompatibilities found between congenic strains which differ at loci determining differentiation antigens.Transplantation. 16:505–514, 1973

    PubMed  Google Scholar 

  • Frelinger, J. A. and Murphy, D. B.: A new alloantigen, Ly-8, recognised by C3H anti-AKR serum.Immunogenetics 3:481–487, 1976

    Google Scholar 

  • Halloran, P. F., Dutton, D., Chance, H., and Cohen, Z.: An Ly-like specificity with extensive nonlymphoid expression.Immunogenetics 7:185–200, 1978

    Google Scholar 

  • Horton, M. A., Beverly, P. C. L., and Simpson, E.: Serological properties of anti-Ly-6.2 srum produced by a new immunization schedule.Immunogenetics 7:173–178, 1978

    Google Scholar 

  • Horton, M. A., Beverly, P. C. L., and Simpson, E.: Expression of Ly-6 alloantigen during differentiation of cytotoxic T cells.Eur. J. Immunol. 9:345–352, 1979

    PubMed  Google Scholar 

  • Kerbel, R. S.: Surface antigen changes accompanying lymphocyte activation.Scand. J. Immunol. 6:1029–1040, 1977

    PubMed  Google Scholar 

  • Kerbel, R. S. and Twiddy, R. R.: A simple and convenient method for producing anti-activated lymphocyte alloantisera which does not require absorption.J. Immunol. Methods 21:11–22, 1978

    PubMed  Google Scholar 

  • McKenzie, I. F. C., Cherry, M., and Snell, G. D.: Ly-6.2: a new lymphocyte specificity of peripheral T cells.Immunogenetics 5:25–32, 1977a

    Google Scholar 

  • McKenzie, I. F. C., Gardiner, J., Cherry, M., and Snell, G. D.: Lymphocyte antigens: Ly-4, Ly-6 and Ly-7.Transplant. Proc. 9:667–669, 1977b

    PubMed  Google Scholar 

  • Sachs, J. A., Huber, B., Pena-Martinez, J., and Festenstein, H.: Genetic studies and effect on skin allograft survival of DBA/2 DAG, Ly, and M-locus antigens.Transplant. Proc 5:1385–1387, 1973

    PubMed  Google Scholar 

  • Snell, G. D.: Editorial, Immunogenetics: Retrospect and ProspectImmunogenetics 1:1–3, 1974

    Google Scholar 

  • Tonkonogy, S. L. and Winn, H. J.: A new alloantigenic system associated with the Mls locus in the mouse.J. Immunol. 116:835–841, 1976

    Google Scholar 

  • Tonkonogy, S. L. and Winn, H. J.: Further genetic and serological analysis of the LyM-1 alloantigen system.Immunogenetics 5:57–64, 1977

    Google Scholar 

  • Woody, J. N.: Ly-6 is a T-cell differentiation antigen.Nature 269:61–63, 1977

    PubMed  Google Scholar 

  • Woody, J. N., Feldmann, M., Beverley, P. C. L., and McKenzie, I. F. C.: Expression of alloantigens Ly-5 and Ly-6 on cytotoxic effector cells.J. Immunol. 118:1739–1743, 1977

    Google Scholar 

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Authors and Affiliations

  1. I.C.R.F. Tumour Immunology Unit, Dept. of Zoology, University College London, Gower Street, London WC1, England

    Michael A. Horton

  2. Dept. of Immunology, London Hospital Medical College, London E1, England

    John A. Sachs

Authors
  1. Michael A. Horton
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  2. John A. Sachs
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Horton, M.A., Sachs, J.A. Identity of murine lymphocyte alloantigens DAG, ALA-1, Ly-8, and Ly-6?. Immunogenetics 9, 273–280 (1979). https://doi.org/10.1007/BF01570421

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