Abstract
Cytotoxic T lymphocyte (CTL) populations from Lewis rats were generated by combined immunization in vivo and restimulation in vitro with lymphoid cells from Fischer 344 donors. This strain combination is phenotypically identical at the MHC (Ag-B) by serologic, MLC, and GVH criteria, and thus, it is to be expected that CTL raised in this combination would show MHC restricted cytolysis against the existing minor alloantigenic differences. Previous studies demonstrated instead that CTL are effective against target cells from a variety of strains, regardless ofMHC haplotype, and that these cytotoxic T cell defined target antigens (“CT antigens”) are controlled by genes which map with the MHC. The present studies show that the CT antigens defined by LαF CTL are unlike gene products expected for eitherSD-like orLD-like region genes, and it is therefore concluded that they mark a novel subregion of the rat MHC or are specified by a locus (loci) linked to, but outside MHC.
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Supported by U.S.P.H. Grants CA-15822, CA-09140, and AI-10961
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Sieck, T., Marshak-Rothstein, A. & Wilson, D.B. Studies of the MHC-linked “CT” alloantigenic systems in rats. Immunogenetics 9, 165–172 (1979). https://doi.org/10.1007/BF01570407
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DOI: https://doi.org/10.1007/BF01570407