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Influence of coumarin treatment on plasma thromboplastin formation and heparin tolerance

With reference to the one-stage quick test

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Summary

  1. 1.

    In patients under long-term anticoagulant therapy with coumarin derivatives, there is a good relationship between the results of Quick time and thromboplastin generation test, and between the results of Quick time and heparin tolerance test, under 30% of Quick value.

  2. 2.

    Below 20–30% of Quick value, there is a true state of “intravascular” hypocoagulability by depressed “plasma thromboplastin” formation and heparin tolerance. This is in agreement with the clinical observation that the Quick value has to be below 20–30% for an efficient hypocoagulability.

Zusammenfassung

  1. 1.

    Bei Patienten, welche unter Antikoagulantien-Langzeittherapie mit Cumarinderivaten stehen, besteht eine gute Beziehung zwischen den Ergebnissen der Quick-Zeit und dem Thromboplastin-Generations-Test und zwischen den Ergebnissen der Quick-Zeit und dem Heparin-Toleranz-Test, wenn sie einen Quick-Wert unter 30% haben.

  2. 2.

    Bei einem Quick-Wert unter 20–30% findet sich eine tatsächliche intravasculäre Hypokoagulabilität durch erniedrigte Plasma-Thromboplastin-Bildung und Heparin-Toleranz. Dies stimmt mit der klinischen Beobachtung überein, daß der Quick-Wert zur Erzielung einer wirksamen Hypokoagulabilität unter 20–30% liegen muß.

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Author notes

  1. R. Holemans & M. Verstraete

    Present address: Universitaire Kliniek St. Rafaël, Capacienevoer 57, Louvain, Belgium

Authors and Affiliations

  1. Laboratory of Physiopathology of the Department of Medicine, University of Louvain, Belgium

    R. Holemans & M. Verstraete

Authors
  1. R. Holemans
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  2. M. Verstraete
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Additional information

Supported by grant-in-aid of the Fonds de la Recherche Clinique Médicale.

Presently Fellow in Hematology, Tufts University School of Medicine, Boston, Mass.

Associée du Fonds National de la Recherche Scientifique.

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Holemans, R., Verstraete, M. Influence of coumarin treatment on plasma thromboplastin formation and heparin tolerance. Blut 8, 29–34 (1962). https://doi.org/10.1007/BF01570369

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  • DOI: https://doi.org/10.1007/BF01570369

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