Abstract
Mice were treated with cyclophosphamide (CY) to induce reversible bone marrow damage and peripheral leukopenia and were infected intraperitoneally withYersinia enterocolitica to study comparatively the effects of both virulent and avirulent isogenic strains on marrow recovery. As a general rule, virulentY. enterocolitica increased the CY-induced damage, whereas the avirulent isogenic derivative improved the marrow recovery. In some instances, infection with virulentY. enterocolitica of CY-pretreated mice resulted in the death of animals.
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Román, S.M., Ruiz-Bravo, A., Jimenez-Valera, M. et al. The influence ofYersinia enterocolitica on the recovery of cyclophosphamide-damaged bone marrow in mice. Current Microbiology 18, 207–209 (1989). https://doi.org/10.1007/BF01570292
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DOI: https://doi.org/10.1007/BF01570292