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Dependence of nitrogen- and phosphorus-regulation of β-lactam antibiotic production byStreptomyces clavuligerus on aeration level

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Journal of Industrial Microbiology

Abstract

Interference with β-lactam production inStreptomyces clavuligerus by ammonium and phosphate ions, normally observed with optimum levels of aeration, was eliminated by restriction of the air supply. Under such a restriction, ammonium slightly stimulated and phosphate markedly stimulated β-lactam antibiotic production. These are rare examples of ‘regulation reversal’ by an environmental modification.

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Authors and Affiliations

  1. Fermentation Microbiology Laboratory, Department of Biology, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA

    A Fang & A L Demain

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  1. A Fang
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  2. A L Demain
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Fang, A., Demain, A.L. Dependence of nitrogen- and phosphorus-regulation of β-lactam antibiotic production byStreptomyces clavuligerus on aeration level. Journal of Industrial Microbiology 15, 407–410 (1995). https://doi.org/10.1007/BF01569965

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  • DOI: https://doi.org/10.1007/BF01569965

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