Summary
Production of 2,3-butanediol byKlebsiella oxytoca was enhanced in the presence of low levels (<8 g/l) of added sodium lactate. Cell growth was inhibited, however, and essentially stopped above 15 g/l added lactate. Levels of by-products (acetic acid and ethanol) were also higher. With 3 g/l lactate and an initial glucose level of 98 g/l, butanediol concentration and productivity increased 164% with 98% utilization of glucose. With high glucose concentration (219 g/l), addition of 2.64 g/l lactate after the growth phase resulted in 81 g/l butanediol, with a productivity of 0.65 g/l/h and 71% glucose utilization.
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Qureshi, N., Cheryan, M. Effect of lactic acid on growth and butanediol production byKlebsiella oxytoca . Journal of Industrial Microbiology 4, 453–456 (1989). https://doi.org/10.1007/BF01569642
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DOI: https://doi.org/10.1007/BF01569642