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CP-61,405, a novel polycyclic pyrrolether antibiotic produced byStreptomyces routienii Huang sp. nov.

  • Original Papers
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Journal of Industrial Microbiology

Summary

CP-61,405 (C26H29N2O7Na) is a novel polycyclic pyrrolether antibiotic produced by a new species,Streptomyces routienii Huang sp. nov. (ATCC 39446). Recovery, fractionation and purification were achieved using standard procedures. The crystalline form includes the CP-61,405 sodium salt, m.p. 334–335°C, [α] 25°CD +315°C (c=1, chloroform). The structure is shown below. CP-61,405 was co-produced with the polycyclic ether antibiotics salinomycin and epi-17-deoxy-(0–8)-salinomycin. It exhibited activity in vitro against gram-positive and anaerobic bacteria, efficacy against poultry coccidia and stimulation in vitro of propionic acid production.

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Authors and Affiliations

  1. Central Research, Pfizer Inc., 06340, Nagoya, Japan

    Walter P. Cullen, Walter D. Celmer, Larry R. Chappel, Liang H. Huang, Mark T. Jefferson & John R. Oscarson

  2. Central Research, Pfizer Inc., 06340, Groton, CT, U.S.A.

    Masaru Ishiguro, Hiroshi Maeda, Satoshi Nishiyama, Riichiro Shibakawa & Junsuke Tone

Authors
  1. Walter P. Cullen
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  2. Walter D. Celmer
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  3. Larry R. Chappel
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  4. Liang H. Huang
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  5. Mark T. Jefferson
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  6. Masaru Ishiguro
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  7. Hiroshi Maeda
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  8. Satoshi Nishiyama
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  9. John R. Oscarson
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  10. Riichiro Shibakawa
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  11. Junsuke Tone
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Cullen, W.P., Celmer, W.D., Chappel, L.R. et al. CP-61,405, a novel polycyclic pyrrolether antibiotic produced byStreptomyces routienii Huang sp. nov.. Journal of Industrial Microbiology 2, 349–357 (1988). https://doi.org/10.1007/BF01569573

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  • DOI: https://doi.org/10.1007/BF01569573

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