Long-term foreign-body reaction to preperitoneal polypropylene mesh in the pig
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The aim of the study is to establish the long-term foreign-body reaction to a polypropylene mesh used for inguinal hernia repair in a pig model. Twenty-two Surpipro® meshes were implanted in 22 preperitoneal inguinal areas in 11 female 10-week-old Yorkshire and Dutch landway swine. The prosthetic mesh was implanted using a laparoscopic transperitoneal technique. At 1, 2, 3, 4, 6, 12 and 26 weeks, the animals were sacreificed and the number of foreign-body giant-cells at the mesh-tissue interface was counted. The mean numbers of giant-cells (SD) after 1, 2, 3, 4, 6, 12 and 26 weeks were: 0.9 (2.4), 7.3 (5.4), 19 (8.2), 15.2 (7.9), 15.9 (6.9), 14.1 (5.6), and 8.2 (4.7). The mean number of giant-cells at 12 weeks was significantly lower than at 3 weeks. The mean number of giant-cells at 26 weeks was significantly lower than at 3, 4, 6, and 12 weeks. We conclude that the foreign-body giant-cell reaction to polypropylene mesh increases until the third week after implantation. Thereafter, it gradually decreases, and at six months it persists at half the maximal level at 3 weeks.
Key wordsInguinal hernia Prosthetic mesh Polypropylene Biocompatibility
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