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Suppression of acquired immunity to infection withSalmonella typhimurium by cyclosporin A

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Abstract

After primary infection of mice withSalmonella typhimurium, the initial, nonspecific phase of resistance was not affected by treatment with cyclosporin A. This agent, when given during but not when given long before a secondary infection, removed considerably but not completely the expression of acquired immunity. This demonstrates again that microorganisms that are opposed mainly by T-lymphocyte-dependent immunity may represent a serious danger for patients treated with cyclosporin A.

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Authors and Affiliations

  1. Institute of Hygiene and Microbiology, University of Würzburg, D-8700, Würzburg, FRG

    Herbert Hof & Richard Strauss

Authors
  1. Herbert Hof
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  2. Richard Strauss
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Hof, H., Strauss, R. Suppression of acquired immunity to infection withSalmonella typhimurium by cyclosporin A. Current Microbiology 13, 177–178 (1986). https://doi.org/10.1007/BF01568942

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  • DOI: https://doi.org/10.1007/BF01568942

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