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Inhibition of in vitro germination and spherulation ofCoccidioides immitis byAllium sativum

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Abstract

An aqueous extract of a dehydrated garlic preparation with uniform consistency inhibited all eight clinical isolates of the dimorphic fungus,Coccidioides immitis. The inhibitory and lethic concentrations were in the range of 3.12–6.25 mg/ml for both the saprophytic (mold) and parasitic (spherule) forms ofC. immitis. At 6.25-mg/ml concentration, the organism lost its viability within 6 h. The conversion of arthroconidia into spherules in a chemically defined liquid medium was prevented by garlic extract diluted to 1:320 (3.12 mg/ml). The data indicate that components of garlic readily inhibited the in vitro germination and spherulation of this medically important dimorphic fungus.

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Authors and Affiliations

  1. Department of Biology, Loma Linda University, 92350, Loma Linda, California, USA

    Moses A. Adetumbi

  2. Department of Microbiology, Loma Linda University, 92350, Loma Linda, California, USA

    Benjamin H. S. Lau

Authors
  1. Moses A. Adetumbi
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  2. Benjamin H. S. Lau
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Adetumbi, M.A., Lau, B.H.S. Inhibition of in vitro germination and spherulation ofCoccidioides immitis byAllium sativum . Current Microbiology 13, 73–76 (1986). https://doi.org/10.1007/BF01568284

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  • DOI: https://doi.org/10.1007/BF01568284

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