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Effect of lincomycin treatment on intestinal microflora composition and its bile-acid-metabolizing activity

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Abstract

We have attempted to determine the influence of lincomycin treatment by oral route on the qualitative and quantitative composition of intestinal microflora and on its activity in deconjugating and 7α-dehydroxylating bile acids. Fresh feces from ten patients without preexisting bowel disease were analyzed before and after antibiotic therapy. Our results show that, after antibiotic therapy, the number of microorganisms that 7α-dehydroxylate cholic and chenodeoxycholic acids was greatly decreased, whereas no significant alteration was observed in the total count of microorganisms deconjugating taurocholic and glycocholic acids.Bacteroidaceae and bifidobacteria were almost completely eliminated, and lactobacilli and coliforms were significantly reduced, whereas the number of anaerobic microorganisms was virtually unaffected.

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Authors and Affiliations

  1. Institute of Agricultural and Technical Microbiology, University of Milan, Via Celoria 2, I-20133, Milan, Italy

    Enrica Canzi,  Annamaria Ferrari & Novella Pacini

  2. Institute of Veterinary Microbiology and Immunology, University of Milan, Via Celoria 2, I-20133, Milan, Italy

    Anna Ceccarelli

  3. Medical Division A, Sant' Anna Hospital, Como, Italy

    Edoardo Fesce

Authors
  1. Enrica Canzi
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  2. Anna Ceccarelli
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  3. Annamaria Ferrari
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  4. Edoardo Fesce
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  5. Novella Pacini
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Canzi, E., Ceccarelli, A., Ferrari, A. et al. Effect of lincomycin treatment on intestinal microflora composition and its bile-acid-metabolizing activity. Current Microbiology 12, 1–4 (1985). https://doi.org/10.1007/BF01567743

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