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Human immunoglobulin-G subclass distribution in response to vaccination withVibria cholerae vaccine and procholeragenoid

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Abstract

Immunoglobulin-G (IgG) subclass-specific antibody to cholera toxin andVibrio cholerae lipopolysaccharide in 26 individuals vaccinated withV. cholerae whole cells and procholeragenoid was investigated. An ELISA assay with monoclonal IgG subclass-specific antibodies was employed. The response to vaccination was found to be predominantly of the IgGl (100%) and IgG2 (73%) subclass. The magnitude of the IgG response was greater for the antitoxic compared with the antilipopolysaccharide vaccine component. IgG subclass antibodies evoked in response to immunization had no influence on the overall IgG subclass serum concentrations.

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Authors and Affiliations

  1. Institute for Clinical and Experimental Cancer Research, University of Berne, Berne, Switzerland

    Frantisek Skvaril

  2. Swiss Serum and Vaccine Institute, Berne, Switzerland

    Stanley J. Cryz Jr. & Emil Fürer

Authors
  1. Frantisek Skvaril
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  2. Stanley J. Cryz Jr.
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  3. Emil Fürer
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Skvaril, F., Cryz, S.J. & Fürer, E. Human immunoglobulin-G subclass distribution in response to vaccination withVibria cholerae vaccine and procholeragenoid. Current Microbiology 12, 147–150 (1985). https://doi.org/10.1007/BF01567667

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  • DOI: https://doi.org/10.1007/BF01567667

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