The Psychiatric Quarterly

, Volume 29, Issue 1–4, pp 433–438 | Cite as

Studies on mescaline III. Action in epileptics

Clinical observations and effects on brain wave patterns
  • Herman C. B. Denberg


  1. 1.

    The intravenous injection of mescaline sulfate in epileptic patients caused an increase, a decrease or a disappearance of alpha activity as shown on the electro-encephalogram.

  2. 2.

    There is either a sharp decrease or disappearance of delta waves.

  3. 3.

    Spike-wave patterns disappear for variable periods following the administration of mescaline.

  4. 4.

    Lethargy, drowsiness and somnolence are the main clinical symptoms produced by mescaline in epileptic patients. All patients denied having auditory or visual hallucinations. Two expressed paranoid ideas, and two had somatic delusions.

  5. 5.

    One patient developed an acute psychotic reaction.

  6. 6.

    Further evidence is offered to support the concept that mescaline acts upon the diencephalon.



Slow Wave Schizophrenic Patient Epileptic Patient Alpha Activity Slow Wave Activity 
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Copyright information

© The Psychiatric Quarterly 1955

Authors and Affiliations

  • Herman C. B. Denberg
    • 1
  1. 1.Manhattan State HospitalWard's Island

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