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Metronidazole-induced susceptibility of adult mice to intestinalClostridium botulinum colonization

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Abstract

Clostridium botulinum type A spore challenges were given orogastrically to adult mice that had been treated with metronidazole. The organism multiplied in the intestinal tract for up to five days if it was administered 9–48 h after the last dose of metronidazole. The known antibacterial spectrum of metronidazole indicated that obligate anaerobic bacteria are important in the natural resistance of adult mice to colonization byC. botulinum, but treatment with the antimicrobial agent did not reduce the number of these bacteria in the cecum and colon.

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Authors and Affiliations

  1. Food Research Institute and Department of Bacteriology, University of Wisconsin, 53706, Madison, Wisconsin, USA

    Donald H. Burr & Hiroshi Sugiyama

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  1. Donald H. Burr
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  2. Hiroshi Sugiyama
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Burr, D.H., Sugiyama, H. Metronidazole-induced susceptibility of adult mice to intestinalClostridium botulinum colonization. Current Microbiology 9, 275–278 (1983). https://doi.org/10.1007/BF01567200

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  • DOI: https://doi.org/10.1007/BF01567200

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