Abstract
Subcutaneous infection withYersinia enterocolitica harboring plasmid responsible for Ca2+ dependence at 37°C induced cell-mediated protective immunity against a lethal challenge withYersinia pestis; the isogenic derivative strain cured from this plasmid subverted the immunity in mice. This is the first identification of the antigen(s) responsible for the induction of cell-mediated protective immunity against the facultatively intracellular bacteria.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
Alonso, J. M., Joseph-Frencois, A., Mazigh, D., Bercovier, H., Mollaret, H. H. 1978. Résistance à la peste de souris expérimentalment infectées parYersinia enterocolitica. Annales de Microbiologie (Paris)192B:203–207.
Alonso, J. M., Vilmer, E., Mazigh, D., Mollaret, H. H. 1980. Mechanisms of acquired resistance to plague in mice infected byYersinia enterocolitica. Current Microbiology4:117–122.
Brubaker, R. R. 1972. The genus Yersinia: Biochemistry and genetics. Current Topics in Microbiology and Immunology57:111–158.
Cavanaugh, D. C., Randall, R. 1959. The role of multiplication ofPasteurella pestis in mononuclear phagocytes in the pathogenesis of fleaborne plague. Journal of Immunology83:348–363.
Ferber, D. M., Brubaker, R. R. 1980. Plasmid inYersinia pestis. Infection and Immunity31:839–841.
Gemski, P., Lazere, J. R., Casey, T. 1980a. Plasmid associated with pathogenicity and calcium dependency ofYersinia enterocolitica. Infection and Immunity27:682–685.
Gemski, P., Lazere, J. R., Casey, T., Wohlhieter, J. A. 1980b. Presence of a virulence-associated plasmid inYersinia pseudotuberculosis. Infection and Immunity28:1044–1047.
Higuchi, K., Smith, J. L. 1961. Studies on the nutrition and physiology ofPasteurella pestis. IV. A differential plating medium for the estimation of the mutation rate to avirulence. Journal of Bacteriology81:605–608.
Schieman, D. A., Devenish, J. A. 1980. Virulence ofYersinia enterocolitica determined by lethality in mongolian gerbils and by Serény test. Infection and Immunity29:500–506.
Wake, A., Morita, H., Wake, M. 1978. Mechanisms of long and short term immunity to plague. Immunology34:1045–1052.
Wake, A. 1980. Genetically controlled natural resistance of mice to plague infection and its relationship to genetically controlled cell-mediated immune resistance, pp. 179–184. In: Skamene, E., Konghavn, P. A. L., Landy, M. (eds.), Genetic control of natural resistance to infection and malignancy, 1st ed. New York: Academic Press.
Wake, A., Sutoh, Y. 1982. Mechanism of protection against virulentYersinia pestis infection without participation of humoral antibody: H-2 restriction in athymic mouse model. Current Microbiology8:79–84.
Zink, D. L., Feeley, J. C., Well, J. G., Vanderzant, C., Vickery, J. C., Roof, W. D., O'Donovan, G. A. 1980. Plasmid-mediated tissue invasiveness inYersinia enterocolitica. Nature (London)283:224–226.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wake, A., Maruyama, T., Akiyama, K. et al. The role of virulence antigens (VW) in the protection of mice againstYersinia pestis infection. Current Microbiology 8, 73–77 (1983). https://doi.org/10.1007/BF01566961
Issue Date:
DOI: https://doi.org/10.1007/BF01566961