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Shedding of intestinal epithelium induced by chlorpromazine as mechanism inhibiting enterotoxin diarrhea

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Abstract

Chlorpromazine, in parallel with reduced fluid accumulation in ligated loops, interfered with the basement membrane and caused shedding of intestinal mucosal epithelium. This was examined by electron microscopy of rat ileum maintained both in vitro and in situ.

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Authors and Affiliations

  1. Norwegian Defence Microbiological Laboratory, Norwegian Institute of Public Health, Geitmyrsveien 75, Oslo 4, Norway

    Ørjan Olsvik

  2. Department of Microbiology, Institute of Pharmacy, University of Oslo, Blindern, P. O. Box 1108, Oslo 3, Norway

    Tom Bergan

  3. Institute of Pharmacy, University of Oslo, Blindern, P. O. Box 1065, Oslo 3, Norway

    Ivar Øye

Authors
  1. Ørjan Olsvik
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  2. Tom Bergan
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  3. Ivar Øye
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Olsvik, Ø., Bergan, T. & Øye, I. Shedding of intestinal epithelium induced by chlorpromazine as mechanism inhibiting enterotoxin diarrhea. Current Microbiology 6, 263–268 (1981). https://doi.org/10.1007/BF01566874

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  • DOI: https://doi.org/10.1007/BF01566874

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