Abstract
Results of immunizations of recombinant inbred and congenic strains of mice with the random polymers poly(glu57 lys38ala5) or GLA5 and poly(glu54lys36ala10) or GLA10 indicate that there is an association of the responsiveness with theH-2 haplotype. Although the C57BL/6J mice (H-2 b haplotype) are “non responders”, the C57BL/6By originally derived from mice of the same haplotype are responders. The immune response pattern of recombinant strains carrying haplotypes derived by crossing over within theH-2 complex indicate that the responsiveness is under control of anIr gene which maps to the left of theIB subregion. Studies with the backcross mice indicated multigenic control of the responsiveness, with one locus beingH-2 linked and another locus segregating independently ofH-2.
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Bailey, D. W.: Recombinant-inbred strains: An aid to finding identity, linkage and function of histocompatibility and other strains.Transplantation 11:325–327, 1971.
Brown, A. M. and Dinsley, M.: Graft of histocompatibility genes in sublines of inbred mice.Nature 212:1602, 1966.
Dorf, M. E., Dunham, E. K., Johnson, J. P., and Benacerraf, B.: Genetic control of the immune response. The effect of non H-2 linked genes on antibody production.J. Immunol. 112:1329–1336, 1974.
Herzenberg, L. A., Warner, N. L., and Herzenberg, L. A.: Immunoglobulin isoantigens (allotypes) in the mouse. I. Genetics and cross reactions of the 7Sγ 2a-isoantigens controlled by alleles at the Ig-1 locus.J. Exp. Med. 121:415–438, 1965.
Hunter, W. M.: The preparation of radioiodinated proteins of high activity, their reaction with antibody in vitro: The radioimmunoassay.In D. M. Weir (ed.):Handbook of Experimental Immunology, pp. 608–654, Davis, Philadelphia, Pa., 1969.
Katchalski, E. and Sela, M.: Synthesis and chemical properties of Poly a amino acids.Adv. Prof. Chem. 13:243–492, 1958.
Kindred, B.: Skin grafting between sublines of inbred strains of mice.Austral. J. Biol. Sci. 16:863–868, 1963.
Klein, J.: The H-2 system: Past and present.Transplant. Proc. 5:11–21, 1973.
Linder, A. E. A.: Skin compatibility of different CBA lines separated from each other in the course of a varying number of generations.Transplantation 1:58–60, 1963.
Markham, R.: A steam distillation apparatus suitable for micro-kjeldahl analysis.Biochem. J. 36:790–791, 1942.
Maurer, P. H. and Merryman, C. F.: Genetic control of immune responses of inbred mice against the terpolymers poly(Glu57Lys38Ala5) and poly(Glu54Lys36Ala10). I.Immunogenetics, 1, 174–183, 1974.
Merryman, C. F. and Maurer, P. H.: Genetic control of immune response to glutamic acid, alanine, tyrosine containing copolymers in mice.J. Immunol. 108:135–141, 1972.
Merryman, C. F. and Maurer, P. H.: Genetic control of immune response to GA, GT, GL, GAT and GLT.Fed. Proc. 32:4372, 1973. (Abstract).
Pinchuck, P. and Maurer, P. H.: Antigenicity of polypeptides (Poly alpha amino acids). Genetic control of immunogenicity of synthetic polypeptides in mice.J. Exp. Med. 122:673–619, 1965.
Silvers, W. K. and Gasser, D. L.: The genetic divergence of sublines as assessed by histocompatibility testing.Genetics 75:671–677, 1973.
Swank, R. T. and Bailey, D. W.: Recombinant inbred lines: Value in the genetic analysis of biochemical variants.Science 181:1249–1251, 1973.
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Maurer, P.H., Merryman, C.F. & Jones, J. Multigenic control of immune responses of inbred mice against the terpolymers poly(Glu57Lys38Ala5) and poly(Glu54Lys36Ala10) and linkage withH-2 haplotype. Immunogenetics 1, 398–406 (1974). https://doi.org/10.1007/BF01564076
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DOI: https://doi.org/10.1007/BF01564076