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Immune response genes in inbred rats. II. Segregation studies of the GT and GA genes and their linkage to the major histocompatibility locus

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Abstract

Genetic analysis of the high responder-non-(or low) responder differences between WF and ACI rats to the synthetic copolymers GT and GA established singleIr-genes for both antigens and dominance for high responder status.Ir-GT andIr-GA are linked to the major histocompatibility locus. It could be demonstrated that only T cells carrying the high responderIr-GT gene undergo in vitro blast transformation to GT. The advantages of the rat systems for further studies of the regulatory role ofIr-genes on the cellular level are discussed.

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Abbreviations

cpm:

counts per minute

DHR:

delayed hypersensitivity reaction

GA:

random synthetic copolymer of L-glutamic acid50, L-alanine50, M.W. 45,000

GT:

random synthetic copolymer of L-glutamic acid50, L-tyrosine50, M.W. 22,000

Ir gene:

immune response gene

MLC:

mixed lymphocyte cultures

LDH:

lactic dehydrogenase

(T,G)-A-L:

branched chain synthetic polymer of poly-L (tyrosine, glutamic acid)-poly-D, L-alanine-poly-L-lysine

ACI:

ACI/MaI

WF:

Wistar Furth

AUG:

August 28807/Cr

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Authors and Affiliations

  1. The Department of Pathology, Harvard Medical School, Boston, Massachusetts

    Dieter Armerding, David H. Katz & Baruj Benacerraf

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  1. Dieter Armerding
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  2. David H. Katz
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  3. Baruj Benacerraf
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Armerding, D., Katz, D.H. & Benacerraf, B. Immune response genes in inbred rats. II. Segregation studies of the GT and GA genes and their linkage to the major histocompatibility locus. Immunogenetics 1, 340–351 (1974). https://doi.org/10.1007/BF01564072

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  • DOI: https://doi.org/10.1007/BF01564072

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