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Complementation ofH-2-linkedIr genes: Use of helper factor to analyze responses to GLPhe

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Abstract

Responses to GLPhe5 were generated in vitro, using the GLPhe helper factor. A plaque assay, using GLPhe-coated SRC, was used to measure antibody responses to GLPhe. Mice of differentH-2 haplotypes were tested for the ability to produce the GLPhe helper factor or to respond to a known GLPhe helper factor. We report here defects in nonresponder mice of different strains in both the production of helper factor and in the capacity to respond to it.

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Authors and Affiliations

  1. ICRF Tumour Immunology Unit, Department of Zoology, University College London, London, England

    Marilyn Baltz & Marc Feldmann

  2. Department of Biochemistry, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania

    Paul H. Maurer & Carmen F. Merryman

Authors
  1. Marilyn Baltz
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  2. Paul H. Maurer
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  3. Carmen F. Merryman
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  4. Marc Feldmann
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Baltz, M., Maurer, P.H., Merryman, C.F. et al. Complementation ofH-2-linkedIr genes: Use of helper factor to analyze responses to GLPhe. Immunogenetics 6, 471–481 (1978). https://doi.org/10.1007/BF01563938

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  • DOI: https://doi.org/10.1007/BF01563938

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