Abstract
Hybrids between the Thy-1− murine myeloma S194 and the Thy-l+ lymphoma BW5147 (Thy-l+) express neither the Thy-1.1 nor the Thy-1.2 antigen on their cell-surface. Subclones isolated from Thy-1− clones express both Thy-1.1 and Thy-1.2 antigens in amounts similar to those present on wild-type Thy-1+ lymphomas, demonstrating that the Thy-1− hybrids retain all the genes necessary for Thy-1 expression. The results are consistent with the idea that myeloma cells have a functional gene which acts to extinguish cell-surface Thy-1 expression in hybrids. The exact mechanism by which the gene acts to produce the Thy-1− phenotype remains to be determined.
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Hyman, R., Stallings, V. Evidence for a gene extinguishing cell-surface expression of the Thy-1 antigen. Immunogenetics 6, 447–458 (1978). https://doi.org/10.1007/BF01563936
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DOI: https://doi.org/10.1007/BF01563936