References
Aasted, B. and Kindt, T.J.: Structural and serological relationships among different antibodies from the same rabbit antiserum. I. Isolation, chemical and allotypic characterization of ten antibody components from one anti-streptococcal serum.Eur. J. Immunol. 6:721–727, 1976a
Aasted, B. and Kindt, T.J.: Structural and serological relationships among different antibodies from the same rabbit antiserum. II. The idiotypes of ten antibody components from an anti-streptococcal serum.Eur. J. Immunol. 6:727–732, 1976b
Baltimore, D.: Is terminal deoxynucleotidyl transferase a somatic mutagen in lymphocytes?Nature 248:409–411, 1974
Bollum, F.J.: Terminal deoxynucleotidyl transferase.In P.D. Boyer (ed.):The Enzymes, Vol. 10, pp. 145–171. Academic Press, New York, 1974
Bosma, M.J., DeWitt, C., Hausman, S.J., Marks, R., and Potter, M.: Serological distinction of heavy chain variable regions (VH subgroups) of mouse immunoglobulins. I. Common VH determinants on the heavy chains of mouse myeloma proteins having different binding sites.J. Exp. Med. 146:1041–1053, 1977
Breathnach, R., Mandel, J.L., and Chambon, P.: Ovalbumin gene is split in chicken DNA.Nature 270:314–319, 1977
Brezin, C. and Cazenave, P.-A.: La reaction croisée entre le motif allotypique Aal des immunoglobulin du lapin et les anticorpsdiriges contre le motif allotypique Aa3: participation des variantes de la specificité Aa1 a cette reaction croissée.Immunochem. 12:241, 1975
Bukhari, A.I., Shapiro, J.A., and Adhya, S.: (eds.)DNA Insertion Elements, Plasmids and Episomes, Cold Spring Harbor Laboratory, Cold Spring, New York, 1977
Capra, J.D. and Kehoe, J.M.: Antibody diversity: is it all coded for by the germ line genes?Scand. J. Immunol. 3:1–4, 1974a
Capra, J.D. and Kehoe, J.M.: Variable region sequences of five human immunoglobulin heavy chains of the VHIII subgroup: definitive identification of four heavy chain hypervariable regions.Proc. Natl. Acad. Sci. U.S.A. 71:845–848, 1974b
Capra, J.D. and Kehoe, J.M.: Structure of antibodies with shared idiotypy: the complete sequence of the heavy chain variable regions of two IgM antigamma globulins.Proc. Natl. Acad. Sci. U.S.A. 71:4032–4036, 1974c
Capra, J.D. and Kehoe, J.M.: Hypervariable regions, idiotypy and the antibody-combining site.Adv. Immunol. 20:1–40, 1975
Capra, J.D. and Kindt, T.J.: Antibody diversity: can more than one gene encode each variable region?Immunogenetics 1:417–427, 1975
Capra, J.D. and Klapper, D.G.: Complete amino acid sequence of the variable domains of two human IgM anti-gamma globulins (Lay/Pom) with shared idiotypic specificities.Scand. J. Immunol. 5:677–684, 1976
Capra, J.D., Kehoe, J.M., Williams, R., Feizi, T., and Kunkel, H.G.: Light chain sequences of human IgM cold agglutinins.Proc. Natl. Acad. Sci. U.S.A. 69:40–43, 1972
Capra, J.D., Tung, A., and Nisonoff, A.: Structural studies on induced antibodies with defined idiotypic specificities. I. The heavy chains of A/J mouse anti-p-azophenylarsonate antibodies bearing the cross-reactive idiotype.J. Immunol. 114:1548–1553, 1975
Capra, J.D., Klapper, D.G., Tung, A.S., and Nisonoff, A.: Identical hypervariable regions in light chains of differing VK subgroups.Cold Spring Harbor Symp. Quant. Biol. 41:847–853, 1976
Capra, J.D., Tung, A.S., and Nisonoff, A.: Structural studies on induced antibodies with defined idiotypic specificities. V. The complete amino acid sequence of the light chain variable regions of anti-p-azophenylarsonate antibodies from A/J mice bearing a cross-reactive idiotype.J. Immunol. 119:993–999, 1977
Cazenave, P.-A.: Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits.Proc. Natl. Acad. Sci. U.S.A. 74:5122, 1977
Cebra, J.J., Koo, P.H., and Ray, A.: Specificity of antibodies: primary structural basis of hapten binding.Science 186:263, 1974
Eichmann, K.: Genetic control of antibody specificity in the mouse.Immunogenetics 2:491–506, 1975
Eichmann, K., Coutinho, A., and Melchers, F.: Absolute frequencies of lipopolysaccharide-reactive B cells producing A5A idiotype in unprimed, streptococcal A carbohydrate-primed, anti-A5A idiotype-sensitized and anti-A5A idiotype-suppressed A/J mice.J. Exp. Med. 146:1436–1449, 1977
Farace, M.G., Aellen, M.F., Briand, P.A., Faust, C.H., Vassalli, P., and Mach, B.: No detectable reiteration of genes coding for mouse MOPC 41 immunoglobulin light-chain mRNA.Proc. Natl. Acad. Sci. U.S.A. 73:727–731, 1976
Fathman, C.G., Pisetsky, D.S., and Sachs, D.H.: Genetic control of the immune response to nuclease. V. Genetic linkage and strain distribution of anti-nuclease idiotypes.J. Exp. Med. 145:569–577, 1977
Fleischman, J.B.: Synthesis of the rabbit IgG heavy chain.Cold Spring Harbor Symp. Quant. Biol. 32:233–234, 1967
Gearhart, P.J., Sigal, N.H., and Klinman, N.R.: The monoclonal anti-phosphorylcholine antibody response in several murine strains: genetic implications of a diverse repertoire.J. Exp. Med. 145:876–891, 1977
Green, M.M.: Some observations and comments on mutable and mutator genes inDrosophila.Genetics (Suppl.)73:187–194, 1974
Hood, L., Loh, E., Hubert, J., Barstad, P., Eaton, B., Early, P., Fuhrman, J., Johnson, N., Kronenberg, M., and Schilling, J.: The structure and genetics of mouse immunoglobulins: an analysis of NZB myeloma proteins and sets of BALB/c myeloma proteins binding particular haptens.Cold Spring Harbor Symp. Quant. Biol. 41:817–836, 1976
Horng, W.J., Knight, K.L., and Dray, S.: Heavy chain variable region allotypic sub-specificities of rabbit immunoglobulins. I. Identification of three subpopulations of a1 IgG Molecules.J. Immunol. 116:117–125, 1976
Hozumi, N. and Tonegawa, S.: Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.Proc. Natl. Acad. Sci. U.S.A. 73:3628–3632, 1976
Jeffreys and Flavell: The rabbitβ-globulin gene contains a large insert in the coding sequence.Cell 12:1097–1108, 1977
Johnstone, A.P., Thunberg, A.L., and Kindt, T.J.: A homogeneous rabbit immunoglobulin lacking group a allotypes: amino acid sequence analysis of the heavy chain.Biochem., 17:1337–1344, 1978
Judd, B.:In W. J. Peacock and R. Brock (eds.):The Eukaryotic Chromosome pp. 169–184. Australian National University Press, Canberra, 1975
Kindt, T.J., Klapper, D.G., and Waterfield, M.D.: An idiotypic crossreaction between allotype a3 and allotype a negative rabbit antibodies to streptococcal carbohydrate.J. Exp. Med. 137:636–648, 1973a
Kindt, T.J., Seide, R.K., Bokisch, V.A., and Krause, R.M.: Detection of idiotypic cross-reactions among streptococcal antisera from related rabbits.J. Exp. Med. 138:522–531, 1973b
Klapper, D.G. and Capra, J.D.: The amino acid sequence of the variable regions of the light chains from two idiotypically cross-reactive IgM anti-gamma globulins.Ann. Immunol. (Inst. Pasteur) 127C:261–271, 1976
Klinman, N.R., Sigal, N.H., Metcalf, E.S., Pierce, S.K., and Gearhart, P.J.: The interplay of evolution and environment in B-cell diversification.Cold Spring Harbor Symp. Quant. Biol. 41:165–173,1976
Krawinkel, U., Cramer, M., Berek, C., Hämmerling, G., Black, S.J., Rajewsky, K., and Eichmann, K.: On the structure of the T-cell receptor for antigen.Cold Spring Harbor Symp. Quant. Biol. 41:285–294, 1976
Kuettner, M.T., Wang, A.L., and Nisonoff, A.: Quantitative investigations of idiotypic antibodies. VI. Idiotypic specificity as a potential genetic marker for the variable regions of mouse immunoglobulin polypeptide chains.J. Exp. Med. 135:579–597, 1972
Kunkel, H.G., Agnello, V., Winchester, R.J., and Capra, J.D.: Cross-idiotypic specificities among monoclonal IgM proteins with anti-γ globulin activity.J. Exp. Med. 137:331–342, 1973
Kunkel, H.G., Winchester, R.J., Joslin, F.G., and Capra, J.D.: Similarities in the light chains of antigamma globulins showing cross-idiotypic specificities.J. Exp. Med. 139:128–136, 1974
Leder, P., Honjo, T., Seidman, J., and Swan, D.: Origin of immunoglobulin gene diversity: the evidence and a restriction-modification model.Cold Spring Harbor Symp. Quant. Biol. 41:855–862, 1976
Mach, B., Farace, M.G., Aellen, M.F., Rougeon, F., and Vassalli, P.: Molecular approach to the organization of immunoglobulin genes.Proceedings of the Tenth FEBS Meeting:299–312, 1975
Margolies, M.N., Cannon, L.E., Kindt, T.J., and Fraser, B.: The structural basis of rabbit VH allotypes: serologic studies on al H chains with defined amino acid sequence.J. Immunol. 119:287–294, 1977
McClintock, B.: Controlling elements and the gene.Cold Spring Harbor Symp. Quant. Biol. 21:197–216, 1956
Milstein, C., Brownlee, G.G., Cartwright, E.U., Jarus, J.M., and Proudfoot, N.J.: Sequence analysis of immunoglobulin light chain messenger RNA.Nature (Lond.) 252:354–358, 1974
Oudin, J. and Cazenave, P.-A.: Similar idiotypic specificities in immunoglobulin fractions with different antibody functions or even without detectable antibody function.Proc. Natl. Acad. Sci. U.S.A. 68:2616–2620, 1971
Rabbitts, T.H.: A molecular hybridization approach for the determination of the immunoglobulin V-gene pool size.Immunol. Rev. 36:29–50, 1977
Rabbitts, T.H. and Milstein, C.: Mouse immunoglobulin genes: studies on the reiteration frequency of light-chain genes by hybridization procedures.Eur. J. Biochem. 52:125–133, 1975
Rudikoff, S. and Claflin, L.: Expression of equivalent clonotypes in BALB/c and A/J mice after immunization with phosphorylcholine.J. Exp. Med. 144:1294–1304, 1976
Sambrook, J.: Adenovirus amazes at Cold Spring Harbor.Nature 268:101–104, 1977
Sigal, N.H.: Novel idiotypic and antigen-binding characteristics in two anti-dinitrophenyl monoclonal antibodies.J. Exp. Med. 146:282–286, 1977
Smithies, O., Gibson, B.M., Fanning, E.M., Percy, M.E., Parr, D.M., and Connell, G.E.: Deletions in immunoglobulin polypeptide chains as evidence for breakage and repair in DNA.Science 172:574–577, 1971
Starlinger, P.: DNA rearrangements in prokaryotes.Crit. Rev. Microbiol., in press, 1977
Tonegawa, S., Hozumi, N., Matthyssens, G., and Schuller, R.: Somatic changes in the content and context of immunoglobulin genes.Cold Spring Harbor Symp. Quant. Biology.41:877–889, 1976
Tung, A. S. and Nisonoff, A.: Isolation from individual A/J mice of anti-p-azophenylarsonate antibodies bearing a cross-reactive idiotype.J. Exp. Med. 141:112–126, 1975
Urbain, J., Wikler, M., Franssen, J.D., and Collignon, C.: Idiotypic regulation of the immune system by the induction of antibodies against anti-idiotypic antibodies.Proc. Natl. Acad. Sci. U.S.A. 74:5126, 1977
Williams, R., Kunkel, H.G., and Capra, J.D.: Antigenic specificities related to the cold agglutinin activity of IgM globulins.Science 161:379–381, 1968
Wu, T.T. and Kabat, E.A.: An analysis of the sequences of the variable region of Bence-Jones proteins and myeloma light chains and their implications for antibody complementarity.J. Exp. Med. 132:211–250, 1970
Wu, T.T., Kabat, E.A., and Bilofsky, H.: Similarities among hypervariable segments of immunoglobulin chains.Proc. Natl. Acad. Sci. U.S.A. 72:5107–5110, 1975
Yarmush, M.L., Sogn, J.A., Mudgett, M., and Kindt, T.J.: The inheritance of antibody V regions in the rabbit: linkage of an H-chain specific idiotype to immunoglobulin allotypes.J. Exp. Med. 145:916, 1977
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Kindt, T.J., Capra, J.D. Gene-insertion theories of antibody diversity: A re-evaluation. Immunogenetics 6, 309–321 (1978). https://doi.org/10.1007/BF01563923
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DOI: https://doi.org/10.1007/BF01563923