Abstract
C57BL/6 (H-2 b) mice, when immunized with the sequential polymer (T-G-A-Gly)n and its low-molecular-weight oligomers, respond only to theα-helical oligomers with molecular weights of 9700 and above. Only the sameα-helical oligomers were able to inhibit the homologous antigen-antibody reaction. Random copolymers of GA, GT, and GAT10 did not inhibit. In vitro stimulation of peritoneal exudate lymphocyte (PETLES) cultures showed that the cellular response (T-cell) against (T-G-A-Gly)n is antigen-specific. In vitro antigen-induced stimulation of whole spleen or lymph node lymphocytes indicated that (T-G-A-Gly)n might also be a B-cell mitogen.
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Lai, C.H., Maurer, P.H. Immune responses of mice to poly(L-Tyr-L-Glu-L-Ala-Gly) and its oligomers. Immunogenetics 6, 283–291 (1978). https://doi.org/10.1007/BF01563920
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DOI: https://doi.org/10.1007/BF01563920