Abstract
Secondary MLR (PLT) can be generated against stimulatory products (PLA), coded for by theHLA-D region, which are either identical or closely related to the Ia-like DRw antigens. Other stimulatory products (PLB), different from the former but probably alsoHLA- linked, have been demonstrated by generating PLTs in PLA phenoidentity between responding and stimulating cells. Likewise, in PLB phenoidentity, PLTs are sensitized only against the PLA products. PLA and PLB products could be different determinants controlled by the same gene(s) or different genes, probably closely linked in theHLA complex.
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Sasportes, M., Nunez-Roldan, A. & Fradelizi, D. Analysis of products involved in primary and secondary allogenic proliferation in man. Immunogenetics 6, 55–68 (1978). https://doi.org/10.1007/BF01563896
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DOI: https://doi.org/10.1007/BF01563896