Abstract
HLA-D typing, primed lymphocyte test (PLT), and DR (Ia-like) serology were compared in a population and family study. A significant positive correlation was observed between theHLA-D region products detected by these three techniques. The strongest correlation observed was between PLT and DR serology, indicating a very close functional similarity between PL and DRw antigens. The DRw antigens and/or PL products appear to be mainly responsible for secondary proliferation. Data are presented which suggest that DRw and/or PL products could be distinct from the Dw products, involved in primary MLR. Nevertheless, a DRw disparity associated with a Dw incompatability is able to increase the intensity of a primary MLR, suggesting that DRw antigens also influence a primary proliferative response.
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Sasportes, M., Fradelizi, D., Nunez-Roldan, A. et al. Analysis of stimulating products involved in primary and secondary allogenic proliferation in man. Immunogenetics 6, 29–42 (1978). https://doi.org/10.1007/BF01563894
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DOI: https://doi.org/10.1007/BF01563894