Abstract
Genetic effects on spontaneous autoimmune thyroiditis in chickens were assessed by measuring phenotypic symptoms, the titer of circulating antibody to thyroglobulin, and the pathological change in the thyroids of young chicks. One or more loci within theB complex (the major histocompatibility complex of the chicken) are responsible for the expression of autoimmunity, and evidence is provided for an interaction of theB haplotype with genes at other loci. The influence of theB complex component on genetic susceptibility is more visible in animals with limited susceptibility at other loci and becomes indistinguishable as the frequency of other genes determining thyroid autoimmunity increases.
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Bacon, L. D., Kite, Jr., J. H., and Rose, N. R.: Immunogenetic detection ofB locus genotypes in chickens with autoimmune thyroiditis.Transplantation 16: 591–598, 1973
Bacon, L. D., Kite, Jr., J. H., and Rose, N. R.: Relation between the major histocompatibility (B) locus and autoimmune thyroiditis in Obese chickens.Science 186: 274–275, 1974
Bacon, L. D., Sundick, R. S., and Rose, N. R.: Genetic and cellular control of spontaneous autoimmune thyroiditis in OS chickens.In A.A. Benedict (ed.):Avian Immunology, pp. 305–315, Plenum Press, New York, 1977
Bacon, L. D., Cole, R. K., Polley, C. R., and Rose, N. R.: Genetic aspects of autoimmune thyroiditis in OS chickens.In N. R. Rose, P. E. Bigazzi, and N. L. Warner (eds.):Genetic Control of Autoimmune Disease, pp. 259–268, Elsevier/North-Holland, New York, 1978
Bacon, L. D. and Rose, N. R.: Influence of major histocompatibility haplotype on autoimmune disease varies in different inbred families of chickens.Proc. Natl. Acad. Sci (U.S.A.) 76: 1435–1437, 1979
Benacerraf, B and Katz, D.H.: The nature and function of histocompatibility-linked immune-response genes.In B. Benacerraf (ed.):Immunogenetics and Immunodeficiency, pp. 117–178, University Park Press, Baltimore, 1975
Bernard, C. C. A.: Experimental autoimmune encephalitis in mice: Genetic control of susceptibility.J. Immunogenet. 3: 263–274, 1976
Bloom, S. E., Cole, R. K., and Bacon, L. D.: Chromosomal localization of the major histocompatibility (B) locus in the chicken.Poult. Sci. 57: 1119, 1978
Bubbers, J. E., Chen, S., and Lilly, F.: Non-random inclusion ofH-2K andH-2D antigens in Friend virus particles from mice of various strains.J. Exp. Med. 147: 340–351, 1978
Chanh, T. C., Benedict, A. A., and Abplanalp, H.: Association of serum hemolytic complement levels with the major histocompatibility complex in chickens.J. Exp. Med. 144: 555–561, 1976
Cole, R. K.: Hereditary hypothyroidism in the domestic fowl.Genetics 53: 1021–1033, 1966
Cole, R. K., Kite, Jr., J. H., Wick, G., and Witebsky, E.: Inherited autoimmune thyroiditis in the fowl.Poult. Sci. 49: 839–848, 1970
Cole, R. K., Kite, Jr., J. H., and Witebsky, E.: Hereditary autoimmune thyroiditis in the fowl.Science 169: 1357–1358, 1968
Druet, E., Sapin, C., Günther, E., Feingold, N., and Druet, P.: Mercuric chloride-induced anti-glomerular basement membrane antibodies in the rat: Genetic control.Eur. J. Immunol. 7: 348–351, 1977
Dupont, B., O'Neill, G. J., Yang, S. Y., Pollack, M. S., and Levine, L. S.: Genetic linkage of disease-genes to HLA.In N. R. Rose, P. E. Bigazzi, and N. L. Warner (eds.):Genetic Control of Autoimmune Disease, pp. 15–25, Elsevier/North-Holland, New York, 1978
Farid, N. R., Newton, R. M., Noel, E. P., Barnard, J. M., and Marshall, W. H.: The operation of immunological networks in Graves' disease.Tissue Antigens 12: 205–211, 1978
Gasser, D. L., Newlin, C. M., Palm, J., and Gonatas, N. K.: Genetic control of susceptibility to experimental allergic encephalomyelitis in rats.Science 181: 872–873, 1973
Günther, E., Odenthal, H., and Wechsler, W.: Association between susceptibility to experimental allergic encephalomyelitis and the major histocompatibility system in congenic rat strains.Clin. Exp. Immunol. 32: 429–434, 1978
Hála, K., Vilhelmová, M., and Hartmanová, J.: The structure of the major histocompatibility complex of the chicken.In A. A. Benedict (ed.):Avian Immunology, pp. 227–232, Plenum Press, New York, 1977
Irvine, W. J.: The immunology and genetics of autoimmune endocrine disease.In N. R. Rose, P. E. Bigazzi, and N. L. Warner (eds.):Genetic Control of Autoimmune Disease, pp. 77–97, Elsevier/North-Holland, New York, 1978
Jaroszewski, J., Sundick, R. S., and Rose, N. R.: Effects of antiserum containing thyroglobulin antibody on the chicken thyroid gland.J. Clin. Immunol. Immunopathol. 10: 95–103, 1978
Kite, J. H., Jr., Wick, G., Twarog, B., and Witebsky, E.: Spontaneous thyroiditis in an obese strain of chickens. II. Investigations on the development of the disease.J. Immunol. 103: 1331–1341, 1969
Kong, Y. M., David, C. S., Giraldo, A. A., ElRehewy, M., and Rose, N. R.: Regulation of autoimmune response to mouse thyroglobulin: Influence of H-2D-end genes.J. Immunol. 123: 15–18, 1979
Maron, R. and Cohen, I. R.: Mutation atH-2K locus influences susceptibility to autoimmune thyroiditis.Nature 279: 715–716, 1979
Moens, H. and Farid, N. R.: Hashimoto's thyroiditis is associated withHLA-DRw3.N. Eng. J. Med. 299: 133–134, 1978
Rose, N. R., Bacon, L. D., Sundick, R. S., and Briles, W. E.: The significance of cellular alloantigens in spontaneous autoimmune thyroiditis (SAT) of OS chickens.In M. E. Gershwin and N. Cohen (eds.):Comparative and Developmental Aspects of Immunity and Disease, pp. 143–153, Pergamon Press, New York, 1978
Stenglein, B., Thoenes, G. H., and Günther, E.: Genetic control of susceptibility to autologous immune complex glomerulonephritis in inbred rat strains.Clin. Exp. Immunol. 33: 88–94, 1978
Svejgaard, A., Christy, M., Nerup, J., Platz, P., Ryder, L. P., and Thomsen, M.: HLA and autoimmune disease with special reference to the genetics of insulin-dependent diabetes.In N. R. Rose, P. E. Bigazzi, and N. L. Warner (eds.):Genetic Control of Autoimmune Disease, pp. 101–110, Elsevier/North-Holland, New York, 1978
Vladutiu, A. O. and Rose, N. R.: Autoimmune murine thyroiditis: Relation to histocompatibility (H-2) type.Science 174: 1137–1139, 1971
Welch, P. C. and Kite, Jr., J. H.: Delayed hypersensitivity in spontaneous and experimentally induced thyroiditis in chickens.Fed. Proc. 30: 306, 1971
Welch, P., Rose, N. R., and Kite, Jr., J. H.: Neonatal thymectomy increases spontaneous autoimmune thyroiditis.J. Immunol. 110: 575–577, 1973
Wick, G., Kite, Jr., J. H., Cole, R. K., and Witebsky, E.: Spontaneous thyroiditis in the obese strain of chickens. III. The effect of bursectomy on the development of disease.J. Immunol. 104: 45–53, 1970a.
Wick, G., Kite, Jr., J. H., Cole, R. K., and Witebsky, E.: Spontaneous thyroiditis in the obese strain of chickens. IV. The effect of thymectomy and thymobursectomy on the development of disease.J. Immunol. 104: 54–62, 1970b
Wick, G., Gundolf, R., and Hála, K.: Genetic factors in spontaneous autoimmune thyroiditis in OS chickens.J. Immunogenet. 6: 177–183, 1979
Williams, M. R. and Moore, M. J.: Linkage of susceptibility to experimental allergic encephalomyelitis to the major histocompatibility locus in the rat.J. Exp. Med. 138: 775–783, 1973
Witebsky, E., Kite, Jr., J. H., Wick, G., and Cole, R. K.: Spontaneous thyroiditis in the obese strain of chickens. I. Demonstration of circulating antibodies.J. Immunol. 103: 708–715, 1969
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Bacon, L.D., Polley, C.R., Cole, R.K. et al. Genetic influences on spontaneous autoimmune thyroiditis in (CS x OS)F2 chickens. Immunogenetics 12, 339–349 (1981). https://doi.org/10.1007/BF01561675
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DOI: https://doi.org/10.1007/BF01561675