Abstract
Herpes-simplex-virus (HSV) specific, H-2k-restricted, immune cytotoxic T lymphocytes also lyse noninfected H-2d target cells. Genetic mapping studies revealed that HSV-specific Dk-restricted CTL cross-react with allogeneic targets expressing Dd alloantigens. Cold target inhibition experiments indicate that only a minority of HSV-specific CTL mediate cross-reactive cytolysis. The data give an example of where the phenomenon of H-2-restricted versus nonrestricted responsiveness is not due to distinct subsets of T cells but solely depends on the antigenic determinants recognized.
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This work was supported by the SFB 107 and the Stiftung Volkswagenwerk.
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Pfizenmaier, K., Jung, H., Kurrle, R. et al. Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk . Immunogenetics 10, 395–404 (1980). https://doi.org/10.1007/BF01561589
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DOI: https://doi.org/10.1007/BF01561589