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Activation or suppression of bactericidal activity of macrophages during a graft-versus-host reaction againstI-A andI-J-region differences, respectively

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Abstract

Systemic graft-versus-host reactions (GVHR) were induced in F1 heterozygous mice by injecting 108 parental lymphocytes. The Anti-Thy 1.2-sensitive, T-cell mediated activation of macrophages was assessed by their increased capacity to destroy a facultative intracellular bacteriumListeria monocytogenes. The difference inMHC regions causing a GVHR that induced high levels of macrophage activation mapped toI-A. In contrast, differences atK orD, in any of the otherH-2 subregions or in the non-H-2 background, includingMls alone or in combination, did not induce a GVHR leading to macrophage activation, unless these differences were combined with a difference atI-A. The numbers of parental cells needed to activate macrophages via a GVHR caused byI-A vs. non-I-A differences, varied at least 30- to 100-fold. When parental cells were injected into F1 offspring of parents differing atI-J, growth ofListeria was enhanced significantly; this negative effect on macrophages was not seen when parental combinations differing atI-A alone were compared with those differing atI-A plusI-J orI-J plus otherH-2 regions.

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  1. Rolf M. Zinkernagel

    Present address: Institute of Pathology, Universitätsspital, 8091, Zürich, Switzerland

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  1. Department of Immunopathology, Scripps Clinic and Research Foundation, 92037, La Jolla, California

    Rolf M. Zinkernagel

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Zinkernagel, R.M. Activation or suppression of bactericidal activity of macrophages during a graft-versus-host reaction againstI-A andI-J-region differences, respectively. Immunogenetics 10, 373–382 (1980). https://doi.org/10.1007/BF01561587

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  • DOI: https://doi.org/10.1007/BF01561587

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