Abstract
Alloreactive cytotoxic antibodies were induced in BALB/c mice by syngeneic immunization with normal lymphoid cells. Sixteen out of 41 mice produced antibodies with distinct anti-H-2 specificity. Anti-Kk antibodies were present in all positive sera, but the individual sera produced different reactivity patterns when tested on a panel ofH-2 haplotypes. Absorption and immunoprecipitation experiments confirmed the H-2 specificity of the syngeneic sera.
We hypothesize that virus-modified H-2d structures have triggered alloreactive B-cell clones to produce anti-H-2 antibodies.
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The investigations were supported in part by the Foundation for Medical Research FUNGO which is subsidized by the Netherlands Organization for Advancement of Pure Research (ZWO).
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Iványi, P., van Mourik, P., Breuning, M. et al. Anti-H-2 antibodies induced by syngeneic immunization. Immunogenetics 10, 319–332 (1980). https://doi.org/10.1007/BF01561582
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DOI: https://doi.org/10.1007/BF01561582