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Hierarchy ofH-2 haplotypes governs inheritance of immune responsiveness to TNP-MSA

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Abstract

Production of indirect TNP-specific plaque-forming cells (PFC) in response to immunization with 2, 4, 6-trinitrophenyl (TNP) conjugated to autogenous mouse serum albumin (MSA) in complete Freund's adjuvant (CFA) is underH-2 control. On the C57BL/10 (B10) background,H-2 b andH-2 d strains of mice are high responders, whereasH-2 a,H-2 k orH-2 y2 strains yield low levels of indirect TNP-specific PFC. An unusual pattern of inheritance has been revealed in B10 congenic mice: high responsiveness controlled byH-2 b is inherited recessively, while high responsiveness controlled byH-2 d is inherited dominantly. On the C3H and A strain backgrounds, high responsiveness controlled byH-2 b is partially recessive;H-2 b/H-2 a F1 mice respond with 20%-40% of the high responderH-2 b response. Yet, high responsiveness controlled by theH-2 d haplotype remains dominant on the C3H background. A hierarchy of haplotypes in order of decreasing immune responsiveness to TNP-MSA is evident as follows:H-2 d>H-2 b>H-2 k,H-2 a orH-2 y2. The unusual patterns of inheritance in the TNP-MSA system reveal graded regulation of responsiveness attributable to bothH-2 and non-H-2 genes.

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  1. Immunogenetics Group, Department of Microbiology and Immunology, School of Medicine, University of California, 90024, Los Angeles, California

    Linda S. Wicker, Walter J. Urba & William H. Hildemann

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  1. Linda S. Wicker
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  2. Walter J. Urba
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  3. William H. Hildemann
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Wicker, L.S., Urba, W.J. & Hildemann, W.H. Hierarchy ofH-2 haplotypes governs inheritance of immune responsiveness to TNP-MSA. Immunogenetics 10, 235–246 (1980). https://doi.org/10.1007/BF01561572

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  • DOI: https://doi.org/10.1007/BF01561572

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