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Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13 → q23 region of chromosome 5

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Somatic Cell and Molecular Genetics

Abstract

We have used hamster cDNA probes for 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase (HMGCR) to determine the chromosomal location of the human gene for HMG CoA reductase. Southern blot analysis of genomic DNA from 16 independent mouse-human somatic cell hybrids showed that the human gene for HMG CoA reductase resides on chromosome 5. Analysis of Chinese hamster-human somatic cell hybrids selectively retaining human 5 or a portion of it showed that the gene locus for HMG CoA reductase can be assigned to the q13 → q23 region of chromosome 5.

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Authors and Affiliations

  1. Division of Medical Genetics, Harbor-UCLA Medical Center, 90509, Torrance, California

    T. Mohandas

  2. Department of Medicine, University of California, Los Angeles School of Medicine, 90024, Los Angeles, California

    C. Heinzmann, R. S. Sparkes, P. Edwards & A. J. Lusis

  3. Department of Biological Chemistry, California College of Medicine, University of California, Irvine, 92717, Irvine, California

    J. Wasmuth

  4. Department of Biological Chemistry, University of California, Los Angeles School of Medicine, 90024, Los Angeles, California

    P. Edwards

Authors
  1. T. Mohandas
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  2. C. Heinzmann
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  3. R. S. Sparkes
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  4. J. Wasmuth
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  5. P. Edwards
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  6. A. J. Lusis
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Mohandas, T., Heinzmann, C., Sparkes, R.S. et al. Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13 → q23 region of chromosome 5. Somat Cell Mol Genet 12, 89–94 (1986). https://doi.org/10.1007/BF01560731

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  • DOI: https://doi.org/10.1007/BF01560731

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