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The relation between serum sex steroid levels and plasma cell infiltrates in endometritis

Archives of Gynecology and Obstetrics volume 244, pages 185–191 (1989)Cite this article

Summary

We measured serum levels of progesterone and estradiol among 35 patients with endometritis confirmed by endometrial biopsy. The onset of symptoms took place predominantly in the proliferative phase of the cycle. A negative correlation was found between the serum progesterone levels and the histopathologic severity of plasma cell endometritis. Our results suggest that the hormonal status contributes to the immune response and susceptibility to endometrial infection.

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References

  1. Ahlqvist J, Andersson L (1972) Methyl green-pyronin staining: effects of fixation; use in routine pathology. Stain Technol 47:17–22

    PubMed  Google Scholar 

  2. Chipperfield EJ, Evans BA (1975) Effect of local infection and oral contraception on immunoglobulin levels in cervical mucus. Infect Immun 11:215–221

    PubMed  Google Scholar 

  3. Crum CP, Egawa K, Fenoglio CM, Richart RM (1983) Chronic endometritis: the role of immunohistochemistry in the detection of plasma cells. Am J Obstet Gynecol 147:812–815

    PubMed  Google Scholar 

  4. Eschenbach DA, Harnisch JP, Holmes KK (1977) Pathogenesis of acute pelvic inflammatory disease: role of contraception and other risk factors. Am J Obstet Gynecol 128:838–850

    PubMed  Google Scholar 

  5. Grossman CJ (1985) Interactions between the gonadal steroids and the immune system. Science 227:257–259

    PubMed  Google Scholar 

  6. Heinonen PK, Teisala K, Punnonen R, Miettinen A, Lehtinen M, Paavonen J (1985) Anatomic sites of upper genital tract infection. Obstet Gynecol 66:384–389

    PubMed  Google Scholar 

  7. Hallberg T, Wölner-Hanssen P, Mårdh P-A (1985) Pelvic inflammatory disease in patients infected with Chlamydia trachomatis: in vitro cell mediated immune response to chlamydial antigens. Genitourin Med 61:247–251

    PubMed  Google Scholar 

  8. Hsueh AJW, Peck EJ, Clark JH (1976) Progesterone antagonism of the oestrogen receptor and oestrogeninduced uterine growth. Nature (London) 254:337–339

    Google Scholar 

  9. Hsueh AJW, Peck EJ, Clark JH (1976) Control of uterine estrogen receptor levels by progesterone. Endocrinology 98:438–444

    PubMed  Google Scholar 

  10. Kita E, Takahashi S, Yasui K, Kashiba S (1985) Effect of estrogen (17β-estradiol) on the susceptibility of mice to disseminated gonococcal infection. Inf Immun 49:238–243

    Google Scholar 

  11. Lehtinen M, Rantala I, Aine R, Miettinen A, Laine S, Heinonen P, Peisala K, Punnonen R, Paavonen J (1986) B-cell response in Chlamydia trachomatis endometritis. Eur J Clin Microbiol 5:596–598

    PubMed  Google Scholar 

  12. Matsuda H, Okuda K, Fukui K, Kamata Y (1985) Inhibitory effect of estradiol-17β and progesterone on bactericidal activity in uteri of rabbits infected with Escherichia coli. Infect Immun 48:652–657

    PubMed  Google Scholar 

  13. McDermott MR, Clark DA, Bienenstock J (1980) Evidence for a common mucosal immunologic system, II. Influence of the estrous cycle on B immunoblast migration into genital and intestinal tissue. J Immunol 124:2536–2539

    PubMed  Google Scholar 

  14. Morris H, Edwards J, Tiltman A, Emms M (1985) Endometrial lymphoid tissue: an immunohistological study. J Clin Pathol 38:644–652

    PubMed  Google Scholar 

  15. Mårdth P-A, Ripa KT, Svensson I, Weström L (1977) Chlamydia trachomatis infection in patients with acute salpingitis. N Engl J Med 296:1377–1379

    PubMed  Google Scholar 

  16. Paavonen J, Vesterinen E, Mayer B, Saksela E (1982) Colposcopic and histologic findings in cervical chlamydial infection. Obstet Gynecol 59:712–714

    PubMed  Google Scholar 

  17. Paavonen J, Aine R, Teisala K, Heinonen PK, Lehtinen M, Miettinen A, Punnonen R, Grönroos P (1985) Chlamydial endometritis. J Clin Pathol 38:726–732

    PubMed  Google Scholar 

  18. Paavonen J, Teisala K, Heinonen PK, Aine R, Laine S, Lehtinen M, Miettinen A, Punnonen R, Grönroos P (1987) Microbiological and histopathological findings in acute pelvic inflammatory disease. Br J Obstet Gynecol 94:454–460

    Google Scholar 

  19. Paavonen T, Andersson LC, Adlercreutz H (1981) Sex hormone regulation of in vitro immune response. Estradiol enhance human B-cell maturation via inhibition of suppressor T-cells in pokeweed mitogen-stimulated cuiltures. J Exp Med 154:1935–1941

    PubMed  Google Scholar 

  20. Paavonen T (1985) Hormonal regulation of human lymphocyte functionsin vitro. Academic Dissertation, University of Helsinki

  21. Pasley JN, Rank RG, Hough AJ, Cohen C, Barron AL (1985) Absence of progesterone effects on chlamydial genital infection in female guinea pigs. Sex Transm Dis 12:155–158

    PubMed  Google Scholar 

  22. Pasley JN, Rank RG, Hough AJ Jr Cohen C, Barron AI (1985) Effects of varying doses of estradiol on chlamydial genital infection in ovariectomized guinea pigs. Sex Transm Dis 12:8–13

    PubMed  Google Scholar 

  23. Rank RG, White HJ, Hough AJ, Pasley JN, Barrow AL (1982) Effects of estradiol on chlamydial genital infection of female guinea pigs. Infect Immun 38, 699–705

    PubMed  Google Scholar 

  24. Rantala I, Mäki M, Laasonen A, Visakorpi JK (1985) Periodate-lysine-paraformaldehyde (PLP) as the only fixative for the study of duodenal mucosa. Morphologic and immunohistochemical results at light and electron microscopic levels. Acta Pathol Microbiol Immunol Scand 93:165–172

    Google Scholar 

  25. Santoli D, Trinchieri G, Zmijewski CM, Koprowski H (1976) HLA-related control of spontaneous and antibody-dependent cell-mediated cytotoxic activity in humans. J Immunol 117:765–769

    PubMed  Google Scholar 

  26. Sweet RL, Blankfort-Doyle M, Robbie MO, Schacter J (1986) The occurence of chlamycial and gonococcal salpingitis during the menstrual cycle. JAMA 255:2062–2064

    PubMed  Google Scholar 

  27. Svensson L, Weström L, Mårdh PA (1984) Contraceptives and acute salpingitis. JAMA 251:2553–2555

    PubMed  Google Scholar 

  28. Tuffrey M, Taylor-Robinson D (1981) Progesterone as a key factor in the development of a mouse model for genital-tract infection with chlamycia trachomatis. FEMS Microbiol Lett 12:111–115

    Google Scholar 

  29. Washington AE, Gove S, Schachter J, Sweet RL (1985) Oral contraceptives, Chlamydia trachomatis infection and pelvic inflammatory disease. A word of caution about protection. JAMA 253:2246–2250

    PubMed  Google Scholar 

  30. Wira CR, Sandoe CP (1977) Sex steroid hormone regulation of IgA and IgG in rat uterine secretions. Nature (London) 268:534–536

    Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Tampere University Central Hospital, University of Tampere, Medical School, SF-33520, Tampere, Finland

    R. Punnonen, M. Lehtinen, K. Teisala, R. Aine, I. Rantala, P. K. Heinonen, A. Miettinen, S. Laine & J. Paavonen

Authors
  1. R. Punnonen
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  2. M. Lehtinen
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  3. K. Teisala
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  4. R. Aine
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  5. I. Rantala
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  6. P. K. Heinonen
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  7. A. Miettinen
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  8. S. Laine
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  9. J. Paavonen
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Punnonen, R., Lehtinen, M., Teisala, K. et al. The relation between serum sex steroid levels and plasma cell infiltrates in endometritis. Arch Gynecol Obstet 244, 185–191 (1989). https://doi.org/10.1007/BF01560082

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  • DOI: https://doi.org/10.1007/BF01560082

Key words

  • Estradiol
  • Progesterone
  • Endometritis
  • Plasma cells