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A case report of hepatoblastoma treated by chemotherapy and hepatic lobectomy

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Abstract

A hepatoblastoma in a 2-year-old child was considered unresectable at exploratory laparotomy because of diffuse liver involvement. The treatment of the patient with intravenous 5-fluorouracil for 5 months resulted in a remarkable reduction in the size of the tumor so that it became resectable and was removed by right hepatic lobectomy. The child is alive and well 26 months after surgery. Several similar cases have been reported in which an unresectable hepatoblastoma was made resectable by chemotherapy, and operation was then followed by long-term survival without recurrence.

Résumé

Chez un enfant de 2 ans, la laparotomie révèle un hépatoblastome impossible à réséquer à cause d'un envahissement diffus du foie. L'enfant est traité pendant 5 mois par 5-fiuorouracil intraveineux, avec une telle réduction du volume de la tumeur que celle-ci peut Être enlevée par hépatectomie droite. L'enfant est bien portant 26 mois après cette exérèse. D'autres cas semblables ont été publiés, d'hépatoblastomes non résécables au premier abord, mais qui peuvent Être réséqués après chimiothérapie, avec des survies à long terme sans récidive.

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Authors and Affiliations

  1. Istituto di Patologia Chirurgica II, Policlinico Umberto I, University of Rome, Rome, Italy

    Gianfranco Fegiz M.D., Domenico Rosati M.D.,  Francesco Tonelli M.D. & Alberto Donfrancesco M.D.

  2. Department of Oncohematology, Bambin Gesù Hospital, Rome, Italy

    Gianfranco Fegiz M.D., Domenico Rosati M.D.,  Francesco Tonelli M.D. & Alberto Donfrancesco M.D.

Authors
  1. Gianfranco Fegiz M.D.
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  2. Domenico Rosati M.D.
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  3. Francesco Tonelli M.D.
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  4. Alberto Donfrancesco M.D.
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Fegiz, G., Rosati, D., Tonelli, F. et al. A case report of hepatoblastoma treated by chemotherapy and hepatic lobectomy. World J. Surg. 1, 407–412 (1977). https://doi.org/10.1007/BF01556876

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