Abstract
The role of bile in the pathogenesis of chronic gastric ulcer was studied in 10 grown-up miniature pigs. After an observation period of 14–186 days, 4 pigs out of 5 with total diversion of bile into the stomach developed peptic ulcers in the glandular part of the stomach, whereas none of 5 sham operated pigs developed ulcers after an observation period of 150–196 days. This difference was significant (p<0.05). In all 5 pigs with bile diversion the pyloric gland area enlarged at the cost of the fundic gland area, whereas this was not the case in the 5 controls. This difference was also significant (p<0.01). There was no significant change in gastric emptying after the operations. It is concluded that bile can cause gastric ulcer in the pig.
Résumé
Le rÔle de la bile dans la pathogénie de l'ulcère gastrique a été étudié chez 10 porcs nains adultes. Une dérivation totale de la bile dans l'estomac a été réalisée chez 5 animaux:4 ont développé en 14–186 jours des ulcères dans la portion glandulaire de l'estomac. Chez 5 animaux ayant subi le simulacre de la mÊme opération, aucun ulcère n'est apparu en 150–196 jours. La différence est significative (p<0.05). Chez les 5 porcs à dérivation biliaire, la zone pylorique était élargie aux dépens de la région fundique, alors qu'il n'y avait pas de modification chez les 5 témoins. Cette différence est également significative (p<0.01). Le temps de vidange gastrique n'est pas modifié par l'opération. La bile peut donc Être responsable d'apparition d'ulcères gastriques chez le porc.
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This study was supported by grants from Konsul Johs. Fogh-Nielsen og Hustru's legat, F.L. Schmidt & Co. A/S′ Jubilaeumsfond, and the Danish Medical Research Council (Grant No. 512-4226)
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Rokkjaer, M., Søgaard, H., Kruse, A. et al. Bile induced chronic gastric ulcer in swine. World J. Surg. 1, 371–377 (1977). https://doi.org/10.1007/BF01556863
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DOI: https://doi.org/10.1007/BF01556863