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Conservative treatment of breast cancer: A trial in progress at the cancer institute of Milan

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Abstract

In 1973, a clinical trial was started in patients with stage I breast cancer comparing conservative treatment consisting of partial mastectomy plus axillary dissection plus postoperative radiotherapy to the involved breast with conventional radical mastectomy. Patients with positive lymph nodes in the partial mastectomy group have been further randomized to receive either additional radiotherapy to the supraclavicular and internal mammary node areas or no additional radiotherapy. By June 1976, 302 patients had entered the trial. To date there are no significant differences between the conservative and radical surgical treatment groups in regard to local cancer recurrence, the incidence of distant metastases or the development of cancer in the contralateral breast, but it is too early to have obtained meaningful results.

Résumé

En 1973, nous avons entrepris, sur des malades atteintes de cancer mammaire au stade I, un essai clinique comparant la mastectomie radicale conventionnelle à la mastectomie partielle avec dissection axillaire et radiothérapie postopératoire sur le sein entrepris. Les patientes du deuxième groupe dont les ganglions axillaires étaient envahis ont été réparties au hasard en deux groupes: le premier sans traitement complémentaire, le second avec radiothérapie additionnnelle des zones ganglionnaires sus-claviculaires et mammaires internes. En juin 1976, l'essai comportait 302 malades. Actuellement, il n'y a pas de différence significative entre les divers groupes en ce qui concerne les récidives locales, les métastases à distance ou le développement d'un cancer mammaire contralatéral. Mais il est encore trop tÔt pour affirmer que ces résultats sont significatifs.

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Veronesi, U. Conservative treatment of breast cancer: A trial in progress at the cancer institute of Milan. World J. Surg. 1, 324–326 (1977). https://doi.org/10.1007/BF01556849

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  • DOI: https://doi.org/10.1007/BF01556849

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