Summary
Adult African green monkeys and young baboons were inoculated with a baboon-derived herpesvirus (0430) which is antigenically related to herpesvirus SA8. The African green monkeys were not clinically affected, but virus could be recovered from explants. In baboons, pathogenicity was inversely related to age. In intratracheally-inoculated newborns and, to a lesser extent, in intravenously-inoculated newborns, the virus produced severe disease accompanied by weight loss, anorexia, malaise, dyspnea and fever. In 2-month and 1-year-old baboons, the virus produced no clinical symptoms. In all cases, recovery of virus from explants was superior to recovery from tissue homogenates using routine methods.
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Eichberg, J., Kalter, S.S., Heberling, R.L. et al. Experimental herpesvirus infection of baboons (Papio cynocephalus) and African green monkeys (Cercopithecus aethiops) and recovery of virus by tissue explants. Archiv f Virusforschung 43, 304–314 (1973). https://doi.org/10.1007/BF01556146
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DOI: https://doi.org/10.1007/BF01556146