Summary
After 95 passages in primary calf kidney cultures rinderpest virus proliferated readily in HeLa cells and produced characteristic cytopathic effects. A growth-curve experiment showed that the titre of intracellular virus was consistently 10–100 fold greater than that of free virus, thus conforming to the pattern usually described for the agents of measles and canine distemper. Whereas HeLa cultures infected with measles virus readily adsorbed erythrocytes ofCercopithecus aethiops (Vervet) andPapio sp. (Baboon), no haemadsorption was noted in rinderpest-infected cultures. The latter also failed to adsorb erythrocytes of rabbits, guinea pigs, sheep, ox and dog.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Adams, J. M., D. T. Imagawa, M. Yoshimori, andR. W. Huntington: Pediatrics18, 888 (1956).
Adams, J. M., andD. T. Imagawa: Proc. Soc. exp. Biol. Med.96, 240 (1957).
Bech, V., andvon P. Magnus: Acta. Path. Microbiol. Scand.42, 75 (1958).
Black, F. L., M. Beissig, andJ. L. Melnick: Proc. Soc. exp. Biol. a. Med.93, 107 (1956).
Black, F. L.: Virology7, 184 (1959).
Bussell, R. H., andD. T. Karzon: Virology18, 589 (1962).
De Maeyer, E., andJ. F. Enders: Proc. Soc. exp. Biol. Med.107, 573 (1961).
Dulbecco, R., andM. Vogt: J. exp. Med.99, 167 (1954).
Ferris, R. D., andW. Plowright: J. Path. Bact.75, 313 (1958).
Imagawa, D. T., P. Goret, andJ. M. Adams: Proc. Nat. Acad. Sci.46, 1119 (1960).
Jacobson, W., andM. Webb: Exp. Cell. Ees.3, 163 (1952).
Kohn, A.: Nature193, 1088 (1962).
Marshall, J. D., W. C. Eveland, andC. W. Smith: Proc. Soc. exp. Biol. Med.98, 898 (1958).
Moura, R. A.: Arch. ges. Virusforsch.11, 487 (1962).
Plowright, W., andR. D. Ferris: J. comp. Path.69, 152 (1959).
Plowright, W.: Ann. N. Y. Acad. Sci.101, 548 (1962 a).
Plowright, W.: Bull. Off. int. Epiz.57, 1 (1962 b).
Buckle-Enders, G.: Am. J. Dis. Childr.103, 297 (1962).
Thompson, W. R.: Baot. Kevs.11, 115 (1948).
Warren, J.: Advances in Virus Research, Vol.7, 27 (1960). Academic Press Inc., New York, U. S. A.
Weler, T. H., andA. H. Goons: Proc. Soc. exp. Biol. Med.86, 789 (1954).
Westwood, J. C. N., I. A. Macpherson, andD. H. J. Turnus: Brit. J. exp. Path.38, 138 (1957).
Author information
Authors and Affiliations
Additional information
Aided by a Research Fellowship Grant from the Deutsche Forschungsgemeinschaft.
Rights and permissions
About this article
Cite this article
Liess, B., Plowright, W. The propagation and growth characteristics of rinderpest virus in HeLa cells. Archiv f Virusforschung 14, 27–38 (1964). https://doi.org/10.1007/BF01555160
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01555160