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An ultrastructural study of subungual exostosis, with special reference to intranuclear inclusions

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A 12-year-old Japanese boy noticed a red nodule on the distal portion of his right great toe about 2 months before entering our clinic. There was evidence of traumatic injury and infection before the appearance of the nodule. Histological examination showed the subcutaneous localization of bony spicules lined by osteoblasts. Haversian canals, which contained blood vessels and connective tissue, were also seen. Electron microscopic examination revealed normal bone structure, but, interestingly, mesenchymal cells that were localized around the tumor had intranuclear inclusions composed of filamentous bundles. From these findings, this case was diagnosed as subungual exostosis. It is suggested that the appearance of intranuclear inclusions, reported here for the first time, is related to the pathogenesis of subungual exostosis.

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Correspondence to Masayori Kagoura.

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Kagoura, M., Toyoda, M. & Morohashi, M. An ultrastructural study of subungual exostosis, with special reference to intranuclear inclusions. Med Electron Microsc 31, 142–146 (1998).

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