Abstract
Three chronic pedophiliac sex offenders were treated individually with medroxyprogesterone acetate (MPA) over a minumum of 3 months. Genital and subjective response to erotic stimulation, nocturnal penile tumescence, self-reporting of sexual urges, and testosterone levels were recorded repeatedly throughout the study. A single-subject reversal design was used and medication was administered through a double-blind procedure. The results showed that self-report of arousal outside of a laboratory setting was unreliable as a measure of the drug effect. In a laboratory setting, however, there appeared to be a significant reduction in the report of arousal to erotic stimuli while genital arousal decreased only slightly. Reversal of these responses occurred in only one subject during a final placebo phase. Nocturnal penile tumescence was significantly decreased during MPA administration and appeared to be related to decreases in total testosterone.
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References
Bancroft, J., Tennent, T., Loucas K., and Cass, J. (1974). Control of deviant sexual behavior of drugs: behavioral effects of oestrogens and anti-androgens.Brit. J. Psychiat. 125: 310–315.
Berlin, F., and Coyle, G. (1981). Sexual deviation syndromes.Johns Hopkins Med. J. 149: 119–125.
Berlin, F., and Meinecke, C. (1981). Treatment of sex offenders with antiandrogenic medication: Conceptualization, review of treatment modalities, and preliminary findings.Am. J. Psychiat. 135: 601–607.
Binkoff, J. A., Zwick, W. R., Abrams, D., Leipman, M. R., Monti, P. M., and Nirenberg, T. D. (1984). Reactions of Alcoholics and Nonalcoholics to Alcohol Cues. American Psychological Association, Toronto, Canada.
Cooper, A., Ismail, A., Phanjoo, A., and Love, D. (1972). Antiandrogen (cyproterone acetate) therapy in deviant hypersexuality.Brit. J. Psychiat. 120: 59–63.
Gagne, P. (1981). Treatment of sex offenders with medroxyprogesterone acetate.Am. J. Psychiat. 138: 644–646.
Langevin, R., Paitich, D., Hucker, S., Newman, S., Ransay, G., Pope, S., Geller, G., and Anderson, C. (1979). The effect of assertiveness training, provera and sex of therapist in the treatment of genital exhibitionism.J. Behav. Ther. Exp. Psychiat. 10: 275–282.
Laschet, V., and Laschet, L. (1975). Antiandrogens in the treatment of sexual deviations in men.J. Steroid Biochem. 6: 821–826.
Money, J. (1968). Discussion on hormonal inhibition of libido in male sex offenders. In Michael, R. (ed.),Endocrinology and Human Behavior Oxford University Press, London.
Nirenberg, T., & Miller, P. (1982). Salivation: An Assessment of Food Craving?Behav. Res. Ther. 20: 405–407.
Ortmann, J. (1980). The treatment of sexual offenders: Castration and antihormone therapy.Int. J. Law Psychiat. 3: 443–451.
Rose, R. (1976). Antiandrogen therapy of sex offenders.Horm. Behav. Psychopathol. 3: 121–124.
Vermeulen, A., Stoica, T., and Verdunck, L. (1971). The apparent free testosterone concentration, and index of androgenicity.J. Clin. Endocrinol. 33: 759.
Walker, P. (1978). The role of antiandrogens in the treatment of sex offenders. In Qualls, C., Wincze, J., and Barlow, D. (eds.),The Prevention of Sexual Disorders: Issues and Approaches. Plenum Press, New York.
Walker, P., and Meyer, W. (1981). Medroxyprogesterone acetate treatment for paraphiliac sex offenders. In Hayes, J. R., Roberts, T. K., and Solway, K. S. (eds.),Violence and the Violent Individual. Spectrum Publications, Jamaica, NY.
Wikler, A. (1965). Conditioning factors in opiate addiction and relapse. In Wilner, D. and Kassenbaum, G. (eds.),Narcotics. McGraw Hill, New York.
Wincze, J., Venditti, E., Barlow, D., and Mavissakalian, M. (1980). The effects of a subjective monitoring task on the physiological measure of genital response to erotic stimulation.Arch. Sex. Behav. 9: 533–545.
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Wincze, J.P., Bansal, S. & Malamud, M. Effects of medroxyprogesterone acetate on subjective arousal, arousal to erotic stimulation, and nocturnal penile tumescence in male sex offenders. Arch Sex Behav 15, 293–305 (1986). https://doi.org/10.1007/BF01550364
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DOI: https://doi.org/10.1007/BF01550364