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Oral therapy in «early chemical diabetes». I. Serial glucose, cholesterol and uric acid responses to phenformin

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Riassunto

Gli AA. hanno studiato i livelli plasmatici di glucosio, colesterolo e acido urico in 38 pazienti diabetici, in differenti stati di compenso, durante untest pomeridiano al glucosio prima e dopo la somministrazione di fenformina. Vengono descritte le variazioni nella risposta al carico di glucosio. Queste osservazioni, che verranno discusse in lavoro successivo, possono fornire importanti spunti sull'uso razionale, le limitazioni e gli inconvenienti della fenformina nel trattamento e nella profilassi del diabete chimico precoce.

Resume

Les AA. ont étudié les niveaux plasmatiques de glucose, cholestérol et acide urique chez 38 patients diabétiques, dans différents états de compensation, au cours d'untest de l'après-midi au glucose avant et après l'administration de phenformine. On décrit les variations de la réaction à la charge de glucose. Ces observations, qui seront discutées dans un travail suivant, peuvent fournir d'importantes idées sur l'usage rationnel, les limitations et les inconvénients de la phenformine dans le traitement et la prophylaxie du diabète chimique précoce.

Resumen

Los AA. han estudiado los niveles plasmáticos de glucosa, colesterol y ácido úrico en 38 pacientes diabéticos, en estadios de compensación differentes, durante untest postmeridiano a la glucosa antes y después de la suministración de fenformina. Se describen las variaciones de la respuesta a la carga de glucosa. Estas observaciones, que serán discutidas en un trabajo sucesivo, pueden dar detalles importantes sobre el uso racional, las limitaciones y los inconvenientes de la fenformina para el tratamiento y la profilaxis de la diábetes química precoz.

Zusammenfassung

Die AA. untersuchten die Plasmaspiegel der Gluose, des Cholesterols sowie der Harnsaeure bei 38 Diabetikern in verschiedenen Kompensationsstadien waehrend eines Nachmittags-Tests mit Glukose vor und nach der Verabreichung von Phenformin. Es werden die Veraenderungen in der Antwort auf die Glukosebelastung beschrieben. Diese Beobachtungen, die in einer kommenden Arbeit disktiert werden, koennen wichtige Anhaltspunkte betr. den rationalen Einsatz, die Grenzen sowie die Unbelstaende des Phenformins in der Behandlung und Prophylaxe des fruehzeitigen chemischen Diabetes liefern.

Summary

The AA. studied the plasma levels of glucose, cholesterol and uric acid in 38 diabetic patients, in various states of decompensation, during a glucose afternoon test before and after phenformin administration. The changes in the response to glucose load are described. These observations, which will be discussed in a further paper, may afford important hints on the rational employ, the limits and the inconveniences of phenformin in treatment and prophylaxis of early chemical diabetes.

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Authors and Affiliations

  1. Mannow Research Laboratory, Palm Beach Institute for Medical Research, 304, 27th Street West Palm Beach, 33407, West Palm Beach, Florida, USA

    H. J. Roberts (Consulting Staff)

  2. St. Mary's Hospital, West Palm Beach, USA

    H. J. Roberts (Consulting Staff)

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Roberts, H.J. Oral therapy in «early chemical diabetes». I. Serial glucose, cholesterol and uric acid responses to phenformin. Acta diabet. lat 6, 728–758 (1969). https://doi.org/10.1007/BF01548084

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  • DOI: https://doi.org/10.1007/BF01548084

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