Riassunto
Centoventicinque diabetici indiani, tutti maschi, di età compresa fra 21 e 60 anni, sono stati trattati con una dieta a scarso contenuto di grassi ed elevato contenuto glucidico e con glibenclamide e tenuti sotto osservazione per 6 mesi. Vi sono stati 10 fallimenti primitivi (8 %). Nei rimanenti 115 casi (92 %) i livelli glicemici preprandiali e postprandiali vennero normalizzati in 2–24 settimane. In parecchi casi, continuando il trattamento, si ebbe un ulteriore miglioramento della tolleranza ai carboidrati. Così, alla fine di 6 mesi, i risultati deltest di tolleranza al glucosio erano normali in 52 casi (41,6 %) ed il risultato deltest di tolleranza al cortisone-glucosio era normale in 1 caso (0,8 %). Non si sono verificati fallimenti secondari. Gli effetti collaterali del farmaco risaltavano per la loro assenza.
Resume
Cent et vingt-cinq indiens mâles diabétiques, d'âge entre 21–60 ans, ont été traités avec une diète pauvre en lipides, elevée en glucides et avec glybenclamide; ils ont été observés pour 6 mois. On signale 10 échecs primitives (8 %). Dans les restants 115 cas (92 %) les niveaux glycémiques préprandiales et postprandiales ont été normalisés en 2–24 semaines. Dans plusières cas, le prolongement du traitement a porté une amélioration de la tolérance aux carbohydrates. A la fin des 6 mois, les résultats du test de tolérance au cortisone-glucose, était normal dans un cas (0,8 %). Il n'y a pas eu des échecs secondaires ni des effets collatérales.
Resumen
Ciento veinte y cinco diabéticos hindúes, todos varones, con edad comprendida entre 21 y 60 años, han sido tratados con dieta de escaso contenido en grasas y elevado contenido glucídico, y con glibenclamida, y puestos bajo observación durante 6 meses. Se registraron 10 fracasos primitivos (8 %). En los 115 casos restantes (92 %) los nivelos glucémicos antes y después de las comidas se normalizaron en 2–24 semanas. En varios casos, continuando el tratamiento, se obtuvo un sucesivo mejoramiento en lo que respecta la tolerancia hacia los hidratos de carbono. De tal manera que al final de seis meses, los resultados del test de tolerancia a la glucosa eran normales en 52 casos (41,6 %); y el resultado del test de tolerancia a la cortisona-glucosa era normal en un caso (0,8 %). No se verificaron fracasos secundarios. Los efectos colaterales del medicamento brillaban por su ausencia.
Zusammenfassung
125 diabetische Inder, alles Maenner im Alter von 21–60 Jahren, wurden mit einer Diaet mit spaerlichem Fett-, reichlichem Kohlenhydratgehalt und Glybenclamid behandelt und ueber 6 Monate unter Beobachtung gestellt. Es wurden 10 primaere Versager (8 %) festgestellt. Bei den restlichen 115 Faellen (92 %) wurden die prae- und post-prandialen Blutzucker-Niveaus innerhalb 2–24 Wochen normalisiert. Bei vielen Faellen erzielte man bei Fortsetzung der Behandlung eine weitere Verbesserung der Kohlenhydrat-Toleranz. Am Ende der 6 Monate waren die Resultate des Glukosetoleranz-Tests in 52 Faellen (41,6 %) und das Resultat des Cortison-Glukosetoleranz-Tests in 1 Fall (0,8 %) normal. Es wurden keine sekundaeren Versager beobachtet; auch Nebeneffekte des Arzneimittels fehlten vollkommen.
Summary
One hundred and twenty-five Indian diabetics, all males, 21–60 years old, were treated with low-fat high-carbohydrate diet and glybenclamide and observed for 6 months. There were 10 (8 %) primary failures. In the remaining 115 cases (92 %) the preprandial and postprandial blood sugar levels were normalised within 2–24 weeks. In several cases, with continued treatment, there was further improvement in the carbohydrate tolerance. Thus, by the end of 6 months, the results of the glucose tolerance test in 52 cases (41.6 %) and the result of cortisone-glucose tolerance test in 1 case (0.8 %), while under treatment, were normal. There were no secondary failures. Side effects of the drug were conspicuous by their absence.
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Work done at Army Hospital, Delhi Cantonment, India.
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Singh, I., Srivastava, M.C. HB 419 (Glybenclamide) in the treatment of diabetes mellitus. Acta diabet. lat 6, 222–240 (1969). https://doi.org/10.1007/BF01548051
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DOI: https://doi.org/10.1007/BF01548051