Skip to main content
SpringerLink
Log in

Variaciones diurnas de la eliminación de insulina en orina

  • Published:
Acta diabetologia latina Aims and scope Submit manuscript

Riassunto

E' stato studiato l'effetto della luce e del periodo di ingestione del cibo sull'eliminazione di insulina nelle urine. Si può dimostrare l'esistenza di un ritmo circadiano e la presenza di due fattori di regolazione per questa eliminazione. Vengono presentate alcune ipotesi concernenti questi fenomeni.

Resume

On a étudié l'effet de la lumière et de la période d'ingestion des aliments sur l'élimination d'insuline par les urines. On peut démontrer l'existence d'un rythme circadien et la présence de deux facteurs de régulation pour cette élimination. On présente quelques hypothèses concernant ces phénomènes.

Resumen

Se estudió el efecto que sobre la eliminación de insulina urinaria ejercen los períodos de luzoscuridad y el horario de administración del alimento. Se demuestra la existencia de un ritmo circadiano de eliminación de dicha hormona, describiéndose dos reguladores del mismo. Se hacen especulaciones fisiopatológicas acerca de su significado.

Zusammenfassung

Es wurde der Effekt des Lichtes und der Einnahme-Periode der Nahrung auf die Insulinausscheidung im Harn untersucht. Man kann das Dasein eines circadianen Rhythmus und die Anwesenheit von zwei Regulierungsfaktoren fuer diese Ausscheidung nachweisen. Es werden einige Hypothesen betr. diese Phaenomene aufgestellt.

Summary

The effect of light and the period of food ingestion upon insulin elimination in urine has been studied. The existence of a circadian rhythm and the presence of two regulating factors for this elimination can be shown. Some speculations concerning these phenomena are presented.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Bibliografia

  1. Chamberlain M. J., Stimmler L.: The Renal Handling of Insulin - J. clin. Invest.46 911, 1967.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Faiman C., Ryan R. J.: Diurnal Cycle in Serum Concentrations of Follicle-Stimulating Hormone in Men - Nature215 857, 1967.

    Article  CAS  PubMed  Google Scholar 

  3. Gagliardino J. J.: Physiological Variations of Insulin Output in Urine - Metabolism17 139, 1968.

    Article  CAS  PubMed  Google Scholar 

  4. Huggett A. S. G., Nixon D. A.: Use of Glucose Oxidase, Proxidase, and O-Dianisidine in Determination of Blood and Urinary Glucose - Lancet2 368, 1957.

    Article  Google Scholar 

  5. Hunter W. M., Rigal W. M.: The Diurnal Pattern of Plasma Growth Hormone Concentration in Children and Adolescents - J. Endocr.34 147, 1966.

    Article  CAS  PubMed  Google Scholar 

  6. Jørgensen K. R.: Immunoassay of Insulin in Human Urine - Acta Endocr. (Kbh.)51 1, 1966.

    Google Scholar 

  7. Lambert A. E., Hoet J. J.: Diurnal Pattern of Plasma Insulin Concentration in the Human -Diabetologia2 69, 1965.

    Article  Google Scholar 

  8. Mac Arthur R. G., Stimmler L.: Urinary Insulin Excretion in Healthy Children and in Siblings of Childhood-Onset Diabetics - Lancet1 1236, 1966.

    Article  Google Scholar 

  9. Mirsky A., Podore C. J., Wachman J., Broh-Kahn R. H.: The Urinary Excretion of Insulin by Normal and Diabetic Subjects - J. clin. Invest.27 515, 1948.

    Article  CAS  PubMed Central  Google Scholar 

  10. Morgan C. R., Lazarow A.: Immunoassay of Insulin: Two Antibody System. Plasma Insulin Levels of Normal, Sub-Diabetic and Diabetic Rats - Diabetes12 115, 1963.

    Article  Google Scholar 

  11. Nichols C. T., Tyler F. H.: Diurnal Variation in Adrenal Cortical Function - Ann. Rev. Med.18 313, 1967.

    Article  CAS  PubMed  Google Scholar 

  12. Rubenstein A. H., Lowy C., Welborn T. A., Rusell Fraser T.: Urine Insulin in Normal Subjects - Metabolism16 234, 1967.

    Article  CAS  PubMed  Google Scholar 

  13. Sorge F., Mentsel G., Schuman G., Brendel A., Pfeiffer E. F.: Sekretionsrhythmik von ACTH und Cortison im Blute von Stoffwechselgesunden, Paradiabetikern und Fettsüchtigen -Abstract no. 119 of the First Meeting of the European Association for the Study of Diabetes. Montecatini Terme, 1965.

  14. Yalow R. S., Berson S. A.: Immunoassay of Endogenous Plasma Insulin in Man - J. clin. Invest.29 1157, 1960.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Research Institute, The Hospital for Sick Children, Toronto, Canada

    Juan J. Gagliardino

  2. Instituto de Fisiología, Facultad de Ciencias Médicas de la Universidad Nacional de La Plata y Comisión de Investigación Científica de la Provincia de Buenos Aires, Calle 60 y 120, La Plata, Buenos Aires, Argentina

    Juan J. Gagliardino

Authors
  1. Juan J. Gagliardino
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Este trabajo fue costeado por el Medical Research Council de Canada, Grant MT-1202.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gagliardino, J.J. Variaciones diurnas de la eliminación de insulina en orina. Acta diabet. lat 6, 197–205 (1969). https://doi.org/10.1007/BF01548049

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01548049

Key-words

Search

Navigation