Riassunto
Una carenza insulinica acuta è stata provocata nei conigli trattati con siero di cavia anti-insulina. Sono state studiate le variazioni del livello della glicemia, degli acidi grassi liberi, dell'acetoacetato, della SGOT, della SGPT, delle transaminasi glutammico-ossalacetica e glutammico-piruvica epatiche e della lattico deidrogenasi epatica. E' stato rilevato un aumento significativo della glicemia e degli acidi grassi liberi, ed anche della glicosuria. Gli altri parametri esaminati sono rimasti invariati. I risultati confermano il fatto che la carenza acuta di insulina provoca un disturbo immediato del metabolismo glucidico e lipidico.
Resume
On a provoqué une carence en insuline aïgue chez des lapins traités au sérum de cobaye antiinsuline. On a étudié les variations de taux de glycémie, des acides gras libres, d'acéto-acétate, de SGOT, de SGPT, des transaminases glutamique oxalacétique et glutamico-pyruvique hépatiques ainsi que de la déshydrogénase lactique hépatique. On a observé une augmentation significative de la glycémie et des acides gras libres, et même de la glycosurie. Les autres paramètres étudiés sont restés inchangés. Les résultats confirment le fait que la carence aïgue en insuline provoque une perturbation immédiate du métabolisme des glucides et des lipides.
Resumen
Una carencia insulínica aguda ha sido provocada en los conejos tratados con suero de cobayo anti-insulina. Han sido estudiadas las variaciones en los niveles de la glucemia, de los ácidos grasos libres, del acetoacetato, de la SGOT, de la SGPT, de las transaminasas glutámico-oxaloacética y glutámico-pirúvica hepáticas y de la láctico-dehidrogenasa hepática. Ha sido puesto de manifiesto un aumento significativo de la glucemia y de los ácidos grasos libres, y también de la glucosuria. Los otros parámetros examinados han quedado invariados. Los resultados ratifican el hecho de que la carencia aguda de insulina provoca una alteración inmediata en el metabolismo de los glúcidos y de los lípidos.
Zusammenfassung
Ein akuter Insulin-Mangelzustand wurde in mit anti-Insulinserum vom Meerschweinchen behandelten Kaninchen hervorgerufen. Es wurden die Veraenderungen des Blutzuckerspiegels, der freien Fettsaeuren, des Azetoazetats, der SGOT, SGPT, der Glutaminsaeure-Oxalessigsaeure-Transaminase und der Glutaminsaeure-Pyruvat-Transaminase, sowie der LDH in der Leber untersucht. Es wurde eine signifikante Steigerung des Blutzuckers, der freien Fettsaeuren und auch des Harnzuckers festgestellt. Die anderen untersuchten Parameter blieben unveraendert. Die Resultate bestaetigen den Tatbestand, dass der akute Insulinmangelzustand eine sofortige Stoerung des Kohlenhydrat- sowie des Fettstoffwechsels ausloest.
Summary
Acute insulin deficiency was produced in rabbits treated with anti-insulin guinea pig serum. The changes in the levels of blood sugar, free fatty acids, aceto-acetate, SGOT, SGPT, liver glutamicoxaloacetic and glutamic-pyruvic transaminases, and liver lactate dehydrogenase were examined. A significant increase of the blood glucose level and the free fatty acids as well as glycosuria was observed. The other examined parameters remained unchanged. The results confirm the statement that acute insulin deficiency causes a prompt impairment of glucose and fat metabolism.
Bibliografia
Armin G., Grant R. T., Wright P. H.: Acute Insulin Deficiency Produced by Separate Injections of Anti-Insulin Serum - J. Physiol. (Lond.)153 131, 1960.
Dole V. P.: A Relation between non-Esterified Fatty Acids in Plasma and the Metabolism of Glucose - J. clin. Invest.35 150, 1956.
Dolkart R. E., Torok E. E., Wright P. H.: Hepatic Enzyme Activities in Rats Made Diabetic with Alloxan and with Guinea Pig Anti-Insulin Serum - Diabetes13 78, 1964.
Gregor W. H., Martin J. M., Williamson J. R., Lacy P. E., Kipnis D. M.: A Study of the Diabetic Syndrome Produced in Rats by anti-Insulin Serum - Diabetes12 73, 1963.
Hugget A., Nixon D.: Enzymic Determination of Blood Glucose -Biochem. J.66 12, 1957.
Mahler R. F.: Some Effects of Anti-Insulin Serum on Glucose Metabolism - 4e Congr. Feder. Intern. Diabète - Medic. et Hyg., Genève, 1961, pag. 627.
Moloney P. J.: Insulin Resistance and Diabetic Syndrome Produced by Antibodies to Insulin - Proc. Sec. Intern. Congr. Endocr., Excerpta med. Found., Amsterdam, 1964, pag. 888.
Moloney P. J., Coval M.: Antigenicity of Insulin: Diabetes Induced by Specific Antibodies - Biochem. J.59 179, 1955.
Schmidt E., Schmidt F.: Untersuchungen über optimale Reaktions-Bedingungen für Enzym-Aktivitätsbestimmungen in Leberextrakten, in Extrakten anderer Organe und im Serum -Enzymol. biol. clin.2 201, 1962.
Sweeney M. J., Ashmore J.: Effects of Acute Insulin Insufficiency in Liver and Adipose Tissue Fatty Acid Synthesis - Metabolism14 516–521, 1965.
Walker P. G.: A Colorimetric Method for the Estimation of Aceto-Acetate - Biochem. J.58 699, 1954.
Wright P. H.: The Production of Experimental Diabetes by Means of Insulin Antibodies -Amer. J. Med.31 892, 1961.
Wright P. H.: Experimental Diabetes Induced by Insulin Antibodies. On Nature and Treatment of Diabetes - Excerpta med. Found. pag. 354, Amsterdam 1964.
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Andreev, D., Hlebarova, M., Noceva, M. et al. Metabolic changes by acute insulin deficiency in rabbits injected with anti-insulin serum. Acta diabet. lat 6, 29–36 (1969). https://doi.org/10.1007/BF01548037
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DOI: https://doi.org/10.1007/BF01548037