Abstract
We report here a case of prostatic melanosis examined immunohistochemically. The patient was a 70-year-old man with prostatic hyperplasia. Six foci with brown pigmentation were found, not only in stromal cells but also in glandular epithelial cells among many pieces of prostatic tissue. Immunohistochemically, only pigment-laden stromal cells were obviously positive with antibodies to S-100 protein and melanoma (HMB45), but not for CD57, while epithelial cells were only positive for CD57 after depigmentation with bleaching. This is the first report demonstrating immunopositivity of stromal cells for antimelanoma antibody (HMB45), which can label reactive or dysplastic but not normal melanocytes. These results clearly demonstrated that pigment-laden stromal cells are neuroectodermal in origin, and probably reactive or dysplastic but not normal melanocytes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Tannenbaum M (1974) Differential diagnosis in uropathology. III. Melanotic lesion of prostate: blue nevus and prostatic epithelial melanosis. Urology 4:617–621
Uehara T, Takayama S, Takemura T, Kasuga T (1991) Foci of stromal melanocytes (so-called blue naevus) of the uterine cervix in Japanese women. Virchows Arch A Pathol Anat 418:327–331
Guillan RA, Zelman S (1970) The incidence and probable origin of melanin in the prostate. J Urol 104:151–153
Langley JW, Weitzner S (1974) Blue nevus and melanosis of prostate. J Urol 112:359–361
Ro JY, Grignon DJ, Ayala AG, Hogan SF, Têtu B, Ordónez NG (1988) Blue nevus and melanosis of the prostate. Am J Clin Pathol 90:530–535
Furusato M, Matsumoto I, Kato H, Takahashi H, Kawashima Y, Wada T, Suzuki M, Aizawa S (1989) Prostatic carcinoma with melanosis. Prostate 15:65–69
Rois CN, Wright JR (1976) Melanosis of the prostate gland: report of a case with neoplastic epithelium involvement. J Urol 115:616–617
Lew S, Richter S, Jelin N, Siegal A (1991) A blue naevus of the prostate: a light microscopic study including an investigation of S-100 protein positive cells in the normal and in the diseased gland. Histopathology (Oxf) 18:443–448
Gardner WA Jr, Spitz WU (1971) Melanosis of the prostate gland. Am J Clin Pathol 56:762–764
Jao W, Fretzin DF (1971) Blue nevus of the prostate gland. Arch Pathol 91:187–191
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ohtsuki, Y., Furihata, M., Sonobe, H. et al. Melanosis of the prostate: an immunohistochemical study. Med Electron Microsc 31, 38–41 (1998). https://doi.org/10.1007/BF01547947
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01547947