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An ultrastructural study of nodular amyloidosis of the tongue

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Abstract

We have treated a patient with a nodular amyloidosis in the center of the dorsum of the tongue. Ultrastructural observations of human amyloidosis have been reported by many investigators, but there have been few reports of nodular amyloidosis of the tongue. Ultrastructural investigation showed a number of amyloid fibrils around and in the plasmocytoid cells, and severe pressure atrophy was found in many stromal cells, especially in endothelial cells.

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References

  1. Kumar V, Cotran R, Robbins SL (1992) Amyloidosis. In: Basic pathology. Saunders, Philadelphia, pp 165–170

    Google Scholar 

  2. Virchow VR (1855) Zur Cellulose-Frage. Virchows Arch Pathol Anat 8:140–144

    Google Scholar 

  3. Aoki N, Kawabe R, Ohmura S, Fujita K (1990) A case of primary amyloidosis forming the nodules in the tongue (in Japanese). Jpn J Oral Maxillofac Surg 36:95–101

    Google Scholar 

  4. Reinish EI, Raviv M, Srolovitz H, Gornitsky M, Quebec M (1994) Tongue, primary amyloidosis, and multiple myeloma Oral Surg Oral Med Oral Pathol 77:121–125

    PubMed  Google Scholar 

  5. Hammersley N, Moos KF (1985) Primary amyloidosis causing macroglossia and respiratory symptoms. Br J Oral Maxillofac Surg 23:445–449

    PubMed  Google Scholar 

  6. Younal F, Sciubba JJ (1993) Nodular amyloidosis. J Oral Pathol Med 22:231–234

    PubMed  Google Scholar 

  7. van der Wal N, Henzen-Logmans S, van der Kwast WAM, van der Waal I (1984) Amyloidosis of the tongue: a clinical and postmortem study. J Oral Pathol 13:632–639

    PubMed  Google Scholar 

  8. Asai T, Sakai N, Furuta Y, Takasu T, Sasaki K, Gotouda H, Inuyana M (1992) Localized amyloidosis of the tongue (in Japanese) Otolaryngol-Head Neck Surg 64:527–531

    Google Scholar 

  9. Yamaoka Y, Suzuki A, Hatakeyama S, Noda M, Hiraga M, Sekiyama S (1978) Median rhomboid glossitis associated with amyloid deposition. Acta Pathol Jpn 28:319–323

    PubMed  Google Scholar 

  10. Kisilevsky R, Axelrad M, Corbett W, Brunet S, Scott F (1977) The role of inflammatory cells in the pathogenesis of amyloidosis. Lab Invest 37:544–553

    PubMed  Google Scholar 

  11. Shira RB (1973) Amyloidosis: its significance in oral surgery. Review of the literature and report of a case. Oral Surg Oral Med Oral Pathol 36:469–481

    PubMed  Google Scholar 

  12. Ishihara T, Uchino F (1991) Morphologic aspect of amyloidosis (in Japanese). Jpn J Clin Med 49:758–774

    Google Scholar 

  13. Zuncker-Franklin D, Franklin ED (1970) Intracellular localization of human amyloid by fluorescence electron microscopy. Am J Pathol 59:23–40

    PubMed  Google Scholar 

  14. Smith A, Speculand B (1985) Amyloidosis with oral involvement. Br J Oral Maxillofac Surg 23:435–444

    PubMed  Google Scholar 

  15. Ishihara T, Takahashi M, Gondo T, Kawano H, Hoshii Y, Tamura S, Uchino F (1995) Amyloidosis designated as intractable disease by the Ministry of Health and Welfare of Japan—a review and its pathogenesis (in Japanese) Yamaguchi Med J 44:297–318

    Google Scholar 

  16. Ishihara RT, Takahashi M, Koga M, Yokota T, Yoshimi Y, Uchino F (1991) Amyloid fibril formation in the rough endoplasmic reticulum of plasma cells from a patient with localized A λ amyloidosis. Lab Invest 64:265–271

    PubMed  Google Scholar 

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Kimijima, Y., Tanaka, N., Mimura, M. et al. An ultrastructural study of nodular amyloidosis of the tongue. Med Electron Microsc 30, 92–96 (1997). https://doi.org/10.1007/BF01545088

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  • DOI: https://doi.org/10.1007/BF01545088

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