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Acta diabetologia latina

, Volume 4, Issue 4, pp 572–590 | Cite as

Associazione di iperlipemia, diabete mellito e obesita' di medio grado

  • Piero Avogaro
  • Gaetano Crepaldi
  • Giuliano Enzi
  • Antonio Tiengo
Lavori Originali

Riassunto

Vengono descritti 6 pazienti con iperlipemia da carboidrati, diabete non chetonurico e obesità di medio grado.

Il trattamento con una dieta ipocalorica a basso contenuto in carboidrati ha comportato diminuzione del peso corporeo e normalizzazione o spiccata riduzione della glicemia a digiuno e della trigliceridemia.

Viene discussa la stretta relazione tra utilizzazione dei carboidrati e le anomalie metaboliche osservate.

Resume

On observe 6 cas de malades avec hyperlipémie due aux carbohydrates, diabète non cétogénique et obésité de degré moyen.

Le traitement avec une alimentation hypocalorique pauvre en carbohydrates a porté à une diminution pondérale et à une normalisation ou à une forte réduction de la glycémie à jeun et de la triglycéridémie.

On discute l'étroit rapport entre utilisation des carbohydrates et les anomalies métaboliques observées.

Resumen

Se describen 6 pacientes con hiperlipemia por carbohidratos, diabetes no quetonúrica y obesidad de mediana gravedad.

El tratamiento con una dieta hipocalórica de bajo contenido en carbohidratos produjo una disminución del peso corporal y la normalización o notable reducción de la glicemia en ayunas y de la trigliceridemia.

Se discute la íntima relación que existe entre la utilización de los carbohidratos y las anomalías metabólicas observadas.

Zusammenfassung

Es werden 6 Patienten mit Kohlehydrat-Hyperlipaemie, Diabetes ohne Ketonurie und mittelmaessiger Fettleibigkeit beschrieben.

Die Behandlung mit einer hypokalorischen Diaet, mit niedrigem Gehalt an Kohlenhydraten, bewirkte Verminderung des Koerpergewichtes sowie Normalisierung oder ausgepraegte Herabsetzung des Nuechternblutzuckers und der Triglyzeridaemie.

Es werden die engen Beziehungen zwischen Kohlenhydrat-Verwertung und den beobachteten metabolischen Anomalien diskutiert.

Summary

Six patients are described presenting carbohydrate-induced hyperlipemia, stable non-ketonuric diabetes and mild obesity.

Treatment with hypocaloric low carbohydrate diet induced a decrease of body weight, normalization or marked decrease of fasting blood sugar and serum triglycerides.

The strict relationship between carbohydrate intake and the observed metabolic abnormalities is discussed.

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Bibliografia

  1. 1).
    Adlersberg D., Wang C.: Syndrome of Idiopathic Hyperlipemia, Mild Diabetes Mellitus and Severe Vascular Damage - Diabetes4 210, 1955.PubMedGoogle Scholar
  2. 2).
    Ahrens E. H., Hirsch J., Oette K., Farquhar J. W., Stein Y.: Carbohydrate-Induced and Fat-Induced Lipemia - Tr. A. Am. Physicians74 134, 1961.Google Scholar
  3. 3).
    Albrink M. J., Davidson P. C.: Impaired Glucose Tolerance in Patients with Hypertriglyceridemia- J. Lab. clin. Med.4 573, 1964.Google Scholar
  4. 4).
    Albrink M. J., Lavietes P. H., Man E. B.: Vascular Disease and Serum Lipids in Diabetes Mellitus. Observations Over Thirthy Years (1931–1961) - Ann. intern. Med.58 305, 1963.PubMedGoogle Scholar
  5. 5).
    Albrink M. J., Man E. B.: Serum Triglycerides in Health and Diabetes -Diabetes7 194, 1958.PubMedGoogle Scholar
  6. 6).
    Albrink M. J., Meigs J. W.: Interrelationship between Skinfold Thickness, Serum Lipids and Blood Sugar in Normal Men - Amer. J. clin. Nutr.15 255, 1964.PubMedGoogle Scholar
  7. 7).
    Albrink M. J., Meigs J. W., Granoff M. A.: Weight Gain and Serum Triglycerides in Normal Men - New Engl. J. Med.266 484, 1962.Google Scholar
  8. 8).
    Antoniades N. H., Bougas J. A., Camerini-Davalos R., Pyle H. M.: Insulin Regulatory Mechanism and Diabetes Mellitus - Diabetes13 230, 1964.PubMedGoogle Scholar
  9. 9).
    Avogaro P., Crepaldi G., Zeni G., Beatrice L.: Aspetti del metabolismo lipidico nell'obesità essenziale. Il comportamento dei lipidi sierici - Acta med. patav.22 227, 1962.Google Scholar
  10. 10).
    Benard H., Dunet R., Gajdos A., Pequinot H., Polonowsky J.: Hyperlipemie essentielle -Sem. Hôp. Paris31 3077, 1955.Google Scholar
  11. 11).
    Bloor W. R.: The Determination of Cholesterol in Blood - J. biol. Chem.24 227, 1916.Google Scholar
  12. 12).
    Boulet P., Lirouze J., Arnavielhe M., Bonny etSchmouker: Hyperlipémie xanthomateuse plethorique. Efficacité spectaculaire de l'hormone de croissance - Bull. Soc. Méd. Paris73 453, 1957.Google Scholar
  13. 13).
    Bürnstein M., Samaille J.: Dosage des Beta-Lipoproteines seriques après precipitation sélective par l'heparine - Presse méd.66 974, 1958.Google Scholar
  14. 14).
    Carteaud A., Mamon H.: Sur les deux cas de xanthomatoses. Hyperlipémie essentielle et xanthomatose familiale; action de l'heparine local - Sem. Hôp. Paris26 1501, 1956.Google Scholar
  15. 15).
    Carton F. K.: Hyperlipemie de l'adulte paraissant essentielle - Soc. Franc. Dermath. Paris, July 1958.Google Scholar
  16. 16).
    Crepaldi G., Avogaro P., Enzi G., Tiengo A.: La terapia dell'iperlipemia essenziale - Settim. Osp.7 528, 1965.Google Scholar
  17. 17).
    Davidson P., Albrink M. J.: Abnormal Plasma Insulin Response with High Plasma Triglycerides Independent of Clinical Diabetes or Obesity - J. clin. Invest.45 1000, 1966.Google Scholar
  18. 18).
    Dole V. P.: Relation between Non-Esterified Fatty Acids in Plasma and Metabolism of Glucose- J. clin. Invest.35 150, 1956.PubMedGoogle Scholar
  19. 19).
    Fredrickson D. S., Lees R. S.: Familial Hyperlipoproteinemia. In:Stanbury J. B., Wyngaarden J. B., Fredrickson D. S.: The Metabolic Basis of Inherited Disease - Mc Graw-Hill, New York, 1966, pag. 429.Google Scholar
  20. 20).
    Fredrickson D. S., Ono L., Davis L.: Lipolytic Activity of Post-Heparin Plasma in Hyperglyceridemia- J. Lipid Res.4 24, 1963.Google Scholar
  21. 21).
    Gordon R. S.: Relationship between Obesity and Diabetes - Metabolism11 819, 1962.PubMedGoogle Scholar
  22. 22).
    Hagedorn H. C., Jensen B. N.: Zur Mikrobestimmung des Blutzuckers mittels Ferricyanid -Biochem. Z.135 46, 1935.Google Scholar
  23. 23).
    Hales C. N.: Plasma Insulin in Diabetes. In:Cameron M. P., O'Connor M.: The Aetiology of Diabetes Mellitus and its Complications - Ciba Foundation, Colloquia on Endocrinology, Vol.15, J. A. Churchill, London 1964, pag. 140.Google Scholar
  24. 24).
    Harris L. V. D., Van Eck W. F., Man E. B., Peters J. B.: Serum Lipids in Diabetic Acidosis -Metabolism2 120, 1953.PubMedGoogle Scholar
  25. 25).
    Kane J. P., Longscope C., Pavlatos F. G., Grodsky G. M.: Studies of Carbohydrates Metabolism in Idiophatic Hypertriglyceridemia - Metabolism14 417, 1965.Google Scholar
  26. 26).
    Karam J. H., Grodsky G. M., Pavlatos F. C., Forsham P. H.: Critical Factors in Excessive Serum Insulin Response to Glucose: Obesity in Maturity-Onset Diabetes and Growth Hormone in Acromegaly - Lancet1 286, 1965.Google Scholar
  27. 27).
    Kennedy E. P.: The Enzymatic Synthesis of Phospholipids and Triglycerides. In:Page I. H.: Chemistry of Lipides as Related to Atherosclerosis - Ch. C. Thomas Springfield, Ill. 1958, pag. 325.Google Scholar
  28. 28).
    Knittle J. L., Ahrens E. H.: Carbohydrate Metabolism in two Forms of Hyperglyceridemia- J. clin. Invest43 485, 1964.PubMedGoogle Scholar
  29. 29).
    Langdon R. G.: The Biosynthesis of Fatty Acids in Cell-Free Preparation of Mammalian Liver. InPage I. H.: Chemistry of Lipids as Related to Atherosclerosis - Ch. C. Thomas, Springfield, Ill. 1958, pag. 291.Google Scholar
  30. 30).
    Man E. B., Peters J. P.: Lipids of Serum in Diabetic Acidosis - J. clin. Invest.13 237, 1934.Google Scholar
  31. 31).
    Man E. B., Peters J. P.: Serum Lipids in Diabetes - J. clin. Invest.14 579, 1935.Google Scholar
  32. 32).
    Movitt E. R., Gerstl B., Sherwood F., Epstein C. G.: Essential Hyperlipemia - Arch. intern. Med.87 79, 1951.Google Scholar
  33. 33).
    Pavel I.: Prevenzione delle complicazioni diabetiche con la profilassi del diabete-malattia -Atti 1° Simp. Intern. sul diabete, Modena 21–22 settembre 1963 - Clin. ter.30 263, 1964.Google Scholar
  34. 34).
    Randle P. M., Garland P. B., Hales C. N., Newsholme E. A.: The Glucose-Fatty Acid Cycle. Its Role in Insulin Sensitivity and the Metabolic Disturbances of Diabetes Mellitus - Lancet1 785, 1963.PubMedGoogle Scholar
  35. 35).
    Reaven G. M., Farquhar J. M.: Relationship between Plasma Triglycerides, Glucose and Insulin Concentration in Patients with Carbohydrate-Induced Lipemia - Program of 48th Meeting of the Endocrine Society, Chicago, June 20–22, 1956.Google Scholar
  36. 36).
    Sanbar S. S., Zweifler A. J., Conway F. J.: Carbohydrate Metabolism in Essential Hyperlipemia- Circulation30 (Suppl. 3), 27, 1964.PubMedGoogle Scholar
  37. 37).
    Sigstad H.: A Family with Mild Diabetes Mellitus, Hyperlipemia and Atherosclerosis - Acta med. scand.177 465, 1965.PubMedGoogle Scholar
  38. 38).
    Stern L., Shapiro B.: A Rapid and Simple Method for the Determination of Esterified Fatty Acids and for Total Fatty Acids in Blood - J. clin. Path.6 158, 1953.PubMedGoogle Scholar
  39. 39).
    Strang J. M.: Obesity. In:Duncan G. G.: Disease of Metabolism - W. S. Saunders Co., Philadelphia 1964, pag. 693.Google Scholar
  40. 40).
    Thannhauser S. J.: Lipidosis - Grune & Stratton, New York 1958, pag. 275.Google Scholar
  41. 41).
    Tiengo A., Enzi G., Avogaro P., Crepaldi G.: Frequenza e significato di un difetto di attività della lipasi lipoproteica nell'iperlipemia essenziale - Acta med. Patav.25 213, 1965.Google Scholar
  42. 42).
    Tiez A., Shapiro B.: The Synthesis of Glycerides in Liver Homogenates- Biochim. Biophys. Acta19 374, 1956.PubMedGoogle Scholar
  43. 43).
    Van Handel E., Zilversmith D. B.: Micromethod for the Direct Determination of Serum Triglycerides - J. Lab. clin. Med.50 152, 1957.PubMedGoogle Scholar
  44. 44).
    Waddel W., Geyer R. P., Hurley N., Stare F. J.: Abnormal Carbohydrate Metabolism in Patients with Hypercholesterolemia and Hyperlipemia - Metabolism7 707, 1958.PubMedGoogle Scholar
  45. 45).
    Yalow R. S., Berson S. A.: Immuno-Assay of Endogenous Plasma Insulin in Man - J. clin. Invest.39 1157, 1960.PubMedGoogle Scholar
  46. 46).
    Zilversmith D. B., Davis A. K.: Microdetermination of Plasma Phospholipids by Thrichloracetic Acid Precipitation - J. Lab. clin. Med.35 155, 1950.PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1967

Authors and Affiliations

  • Piero Avogaro
    • 1
  • Gaetano Crepaldi
    • 2
  • Giuliano Enzi
    • 3
  • Antonio Tiengo
    • 3
  1. 1.PadovaItaly
  2. 2.PadovaItaly
  3. 3.Clinica Medica Generale dell'UniversitàPadovaItaly

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