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Considerazioni sulla proprieta' insulino-legante del siero del soggetto normale e del diabetico mai trattato con insulina

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Riassunto

Gli AA. rilevano che i sieri dell'individuo normale e del diabetico mai trattato con insulina sono provvisti di proprietà insulino-legante di entità analoga. In alcuni sieri, sia del soggetto normale che del diabetico, è presente un'attività insulino-legante superiore ai valori massimi normali, che diminuisce dopo aggiunta di µU 500 di insulina bovina.

Gli AA. fanno alcune considerazioni interpretative su tale fenomeno.

Resume

Les AA. ont observé que le sérum d'un sujet normal et celui d'un diabétique, jamais traité avec insuline, ont la possibilité de lier l'insuline dans la même mesure. Dans certains sérums, soit du sujet normal soit du diabétique, est présente une activité de liaison de l'insuline supérieure aux taux normaux plus élevés; cette activité diminue après administration de µU 500 d'insuline bovine.

Les AA. présentent leurs considérations à propos de ce phénomène.

Resumen

Los AA. observan que los sueros del individuo normal y del diabético nunca tratado con insulina poseen propiedades insulino-ligantes de entidad análoga. En algunos sueros — ya del sujeto normal, ya del diabético — está presente una actividad insulino-ligante superior a los valores máximos normales, que disminuye luego de haber agregado µU 500 de insulina bovina.

Los AA. hacen algunas consideraciones interpretativas de tal fenómeno.

Zusammenfassung

Die AA. stellen fest, daß das Blutserum des normalen Menschen und des Diabetikers, der nie mit Insulin behandelt wurde, ähnliche Insulin-bindende Eigenschaften aufweisen. In manchen Blutseren, sowohl beim normalen, als auch beim diabetischen Menschen, ist eine Insulin-bindende Aktivität vorhanden, die die maximalen normalen Meßwerte überschreitet und nach Zusatz von µU 500 Rinderinsulin sinkt.

Die AA. geben zu diesem Phänomen einige Erläuterungen.

Summary

The AA. report that the sera of normal subjects and diabetics never treated with insulin have similar insulin-binding properties. In a few sera, either from normal or diabetic subjects, an insulinbinding capacity may be found which is higher than maximum normal values and decreases after addition of µU 500 of beef insulin.

The AA. present some explanatory remarks on this phenomenon.

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Authors and Affiliations

  1. Istituto di Patologia Medica e Metodologia Clinica, dell'Universita' di Catania, Italy

    Michele Lunetta, Giuseppe Calcagno, Luciano Motta & Turiddu Lombardo

  2. Insegnamento di Endocrinologia e Patologia Costituzionale, Italy

    Michele Lunetta, Giuseppe Calcagno, Luciano Motta & Turiddu Lombardo

  3. Istituto di Patologia Medica, Ospedale Garibaldi, Catania, Italy

    Michele Lunetta, Giuseppe Calcagno, Luciano Motta & Turiddu Lombardo

Authors
  1. Michele Lunetta
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  2. Giuseppe Calcagno
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  3. Luciano Motta
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  4. Turiddu Lombardo
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Lunetta, M., Calcagno, G., Motta, L. et al. Considerazioni sulla proprieta' insulino-legante del siero del soggetto normale e del diabetico mai trattato con insulina. Acta diabet. lat 5, 201–214 (1968). https://doi.org/10.1007/BF01543868

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