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Hypotheses actuelles concernant le role physiologique du glucagon

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Riassunto

Tra le numerose azioni del glucagone vengono discusse quelle che si suppone abbiano un significato fisiologico. Si hanno così degli effetti del glucagone sul fegato, sul tessuto adiposo e sulla secrezione insulinica. L'A. discute poi il ruolo fisiologico del glucagone: 1) nella ripartizione dei substrati energetici in caso di digiuno o di ipoglicemia; 2) nel periodo post-prandiale. Egli giunge alla conclusione che il concetto unitario del glucagone deve essere modificato e che occorre distinguere da una parte il glucagone di origine pancreatica e dall'altra il o i glucagoni di origine digestiva.

Resume

Parmi les nombreuses actions du glucagon, celles qui sont supposées avoir une signification physiologique sont discutées. Il en est ainsi des effets du glucagon sur le foie, sur le tissu adipeux et sur l'insulino-sécrétion. L'A. discute ensuite le rôle physiologique du glucagon: 1) dans la répartition des substrats énergétiques lors du jeûne ou de l'hypoglycémie; 2) en période post-prandiale. Il en arrive à la conclusion que la conception uniciste du glucagon doit être réformée et qu'il convient de distinguer d'une part le glucagon d'origine pancréatique et d'autre part le ou les glucagons d'origine digestive.

Resumen

Entre las numerosas acciones del glucagón, se discuten aquellas que — según se cree — tengan un significado patológico. De tal manera, se obtienen efectos del glucagón sobre el hígado, el tejido adiposo y la secreción de insulina. El A. discute luego el papel fisiológico del glucagón: 1) en la repartición de los substratos energéticos en ayunas y en hipoglucemia; 2) en períodopost-prandium. Se llega a la conclusión que el concepto unitario del glucagón debe ser modificado, y que cabe distinguir por una parte el glucagón de origen pancreática, y por la otra el (o los) glucagón de origen digestiva.

Zusammenfassung

Von den durch Glukagon bewirkten Effekten werden nur die erörtert, die vermutlich von physiologischer Bedeutung sind. Dasselbe gilt für die durch Glukagon auf Leber, Fettgewebe und Insulin-Sekretion erbrachten Wirkungen. Der Verfasser bespricht danach die physiologische Rolle von Glukagon: 1) bei der Verteilung der Energie-Substrate im Falle von Nüchternheit und Hypoglykämie; 2) nach dem Essen. Der A. schließt daraus, daß die einheitliche Auffassung über Glukagon einer Erneuerung bedarf und deshalb die Unterscheidung der Glukagon-Produktion einerseits durch die Bauchspeicheldrüse und andererseits durch den Verdauungskanal angeraten ist.

Summary

Among the numerous actions of glucagon those of probable physiological significance are here discussed. These are the effects of glucagon on the liver, adipose tissue and insulin secretion. The A. discusses afterwards the physiological role of glucagon: 1) in the distribution of energy substrates in a fasting or hypoglycaemic state; 2) during the postprandial period. He reaches the conclusion that the unitarian concept of glucagon must be changed and that we have to distinguish on one hand glucagon of pancreatic origin and glucagon or glucagons of intestinal origin on the other hand.

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    Pierre Lefebvre

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Lefebvre, P. Hypotheses actuelles concernant le role physiologique du glucagon. Acta diabet. lat 5, 143–159 (1968). https://doi.org/10.1007/BF01543863

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